| Novel drugs to treat hemophilia. | |
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MedLine Citation:
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PMID: 20653467 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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IMPORTANCE OF THE FIELD: Hemophilia management requires replacement of the deficient clotting factor. Inhibitor development complicates treatment, and the implementation of and adherence to prophylaxis, considered the standard of care for severe hemophilia, is hampered by the high cost and the need for frequent intravenous infusions. New, less expensive therapies are needed to reduce morbidities, enhance convenience and improve outcomes. AREAS COVERED IN THIS REVIEW: We conducted a search of the Medline database from 1990 to 2010 for English language articles pertaining to hemophilia drug therapy. More than 4000 citations were obtained and examined for topic relevance. Additionally, proceedings from the American Society of Hematology, International Society on Thrombosis and Hemostasis, World Federation of Hemophilia, National Hemophilia Foundation and European Association for Haemophilia and Allied Disorders and the ClinicalTrials.gov website were reviewed for relevant publications and information. WHAT THE READER WILL GAIN: This article summarizes current research efforts focused on developing less immunogenic and more potent and/or longer-acting clotting factor concentrates that uniquely promote hemostasis, are more affordable and do not require intravenous administration. TAKE HOME MESSAGE: The availability of orally administered clotting factors will truly transform the lives of hemophilia patients and their families and caregivers. |
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Authors:
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Leonard A Valentino; Yousef Ismael; Michele Grygotis |
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Publication Detail:
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Type: Journal Article Date: 2010-07-24 |
Journal Detail:
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Title: Expert opinion on emerging drugs Volume: 15 ISSN: 1744-7623 ISO Abbreviation: Expert Opin Emerg Drugs Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135662 Medline TA: Expert Opin Emerg Drugs Country: England |
Other Details:
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Languages: eng Pagination: 597-613 Citation Subset: IM |
Affiliation:
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Hemophilia and Thrombophilia Center, Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612-3833, USA. lvalentino@rush.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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