Document Detail


Novel diterpenes with cytotoxic, anti-malarial and anti-tuberculosis activities from a brown alga Dictyota sp.
MedLine Citation:
PMID:  17994392     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two new diterpenes, (1E,2R*,3R*,4S*,6E,18S*)-4,18-dihydroxydictyolactone (1) and 8alpha,11-dihydroxypachydictyol A (2), together with fucoxanthin (3) and a known diterpene 4alpha-hydroxycrenulatane (4) were isolated from the methanol extract of the brown alga Dictyota sp. collected from Bangsaen Beach, Thailand. Their structures were determined by spectroscopic data. The relative stereochemistry of 1 was established by NOE difference and NOESY experiments. Compound 1 showed weak anti-tuberculosis activity while 2 displayed strong cytotoxicity against the NCI-H187 cell line, and potent anti-malarial activity. In addition, 3 was active against HSV-1 and malarial parasites.
Authors:
J Jongaramruong; N Kongkam
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Asian natural products research     Volume:  9     ISSN:  1028-6020     ISO Abbreviation:  J Asian Nat Prod Res     Publication Date:    2007 Sep-Dec
Date Detail:
Created Date:  2007-11-12     Completed Date:  2008-05-14     Revised Date:  2009-07-21    
Medline Journal Info:
Nlm Unique ID:  100888334     Medline TA:  J Asian Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  743-51     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Faculty of Science, Burapha University, Bangsaen, Chonburi, Thailand. jongkoln@buu.ac.th
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MeSH Terms
Descriptor/Qualifier:
Algae, Brown / chemistry*
Animals
Antimalarials / chemistry,  isolation & purification*,  pharmacology*
Antitubercular Agents / chemistry,  isolation & purification*,  pharmacology*
Cell Line, Tumor
Diterpenes / chemistry,  isolation & purification*,  pharmacology*
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbial Sensitivity Tests
Molecular Structure
Spectrophotometry, Ultraviolet
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Antitubercular Agents; 0/Diterpenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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