| Novel diagnostic approaches in bing-neel syndrome. | |
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MedLine Citation:
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PMID: 21856555 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The central nervous system (CNS) manifestations of Waldenström's macroglobulinemia (WM) are known as the Bing-Neel syndrome (BNS). Patients with BNS can be classified into Group A and Group B based on the presence of lymphoplasmacytoid (LMP) cells within the brain parenchyma, leptomeninges, dura, and/or cerebrospinal fluid (CSF). To identify characteristic imaging findings for both Group A and Group B patients, we reviewed all 36 cases (26 referenced, 10 unreported) of proven WM with CNS symptoms, CSF analysis and/or biopsy, and magnetic resonance imaging (MRI) of the brain and/or spinal cord. Enhancement on MRI suggests invasion of the central neuraxis by LMP cells, and can help distinguish between Group A and Group B patients. In addition to differentiating true WM lesions in the CNS from ischemia, hyperviscosity events, and demyelinating lesions, evaluation of brain and spinal cord with gadolinium-enhanced MRI has the potential to guide management. |
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Authors:
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K Ina Ly; Florian Fintelmann; Reza Forghani; Pamela W Schaefer; Ephraim P Hochberg; Fred H Hochberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical lymphoma, myeloma & leukemia Volume: 11 ISSN: 2152-2669 ISO Abbreviation: Clin Lymphoma Myeloma Leuk Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-08-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101525386 Medline TA: Clin Lymphoma Myeloma Leuk Country: United States |
Other Details:
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Languages: eng Pagination: 180-3 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Massachusetts General Hospital Cancer Center, Boston, MA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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