| Novel developments in omega-3 fatty acid-based strategies. | |
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MedLine Citation:
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PMID: 21986642 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been attributed with several health benefits, including triglyceride lowering and cardiovascular disease risk reduction. This review focuses on new prescription omega-3 fatty acid products in development and recently published data regarding omega-3 fatty acid effects on arrhythmias, heart failure, and platelet inactivation. RECENT FINDINGS: A free fatty acid form of n-3 PUFA was found to produce a four-fold higher area under the plasma n-3 PUFA curve than prescription omega-3-acid ethyl esters in patients on a low-fat diet. Eicosapentaenoic acid ethyl esters reduced triglyceride without significantly elevating LDL cholesterol in patients with severe hypertriglyceridemia and in those with mixed dyslipidemia. Recent investigations of n-3 PUFA effects on ventricular and atrial arrhythmias, including studies in patients with implanted defibrillators, failed to demonstrate a significant benefit. However, increased fatty fish or n-3 PUFA consumption was associated with a lower rate of hospitalization in heart failure patients. A further important finding was potentiation of the antiplatelet response when n-3 PUFAs were added to aspirin + clopidogrel. SUMMARY: Although n-3 PUFA therapy continues to show promise in the prevention and management of cardiovascular diseases, further research is necessary to more fully elucidate its role in specific disorders. |
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Authors:
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Michael H Davidson; Douglas Kling; Kevin C Maki |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-7 |
Journal Detail:
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Title: Current opinion in lipidology Volume: - ISSN: 1473-6535 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010000 Medline TA: Curr Opin Lipidol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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aUniversity of Chicago Pritzker School of Medicine, Chicago, Illinois bOmthera Pharmaceuticals, Inc., Bedminster, New Jersey cProvident Clinical Research, Biofortis-North America, Glen Ellyn, Illinois, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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