| Novel cyclic peptide, epichlicin, from the endophytic fungus, Epichloe typhina. | |
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MedLine Citation:
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PMID: 17587677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The novel cyclic peptide, epichlicin, was isolated from Epichloe typhina, an endophytic fungus of the timothy plant (Phleum pretense L.). Its structure was determined by NMR studies and by mass spectrometry. Enantiomers of 3-amino tetradecanoic acid, a constituent amino acid of epichlicin, were synthesized as authentic standards. The stereochemistry of each amino acid was elucidated through a combination of the advanced Marfey method and chemical manipulation. Epichlicin showed inhibitory activity toward the spore germination of Cladosporium phlei, a pathogenic fungus of the timothy plant at an IC50 value of 22 nM. |
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Authors:
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Yoshiya Seto; Kosaku Takahashi; Hideyuki Matsuura; Yasunori Kogami; Hiroshi Yada; Teruhiko Yoshihara; Kensuke Nabeta |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 71 ISSN: 0916-8451 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-25 Completed Date: 2007-09-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 1470-5 Citation Subset: IM |
Affiliation:
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Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antifungal Agents
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pharmacology* Cladosporium / drug effects Fungi / chemistry* Molecular Structure Peptides, Cyclic / chemistry*, isolation & purification, pharmacology* Phleum / microbiology Plant Diseases / microbiology Spores / drug effects Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Peptides, Cyclic; 0/epichlicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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