Document Detail

Novel cyclic peptide, epichlicin, from the endophytic fungus, Epichloe typhina.
MedLine Citation:
PMID:  17587677     Owner:  NLM     Status:  MEDLINE    
The novel cyclic peptide, epichlicin, was isolated from Epichloe typhina, an endophytic fungus of the timothy plant (Phleum pretense L.). Its structure was determined by NMR studies and by mass spectrometry. Enantiomers of 3-amino tetradecanoic acid, a constituent amino acid of epichlicin, were synthesized as authentic standards. The stereochemistry of each amino acid was elucidated through a combination of the advanced Marfey method and chemical manipulation. Epichlicin showed inhibitory activity toward the spore germination of Cladosporium phlei, a pathogenic fungus of the timothy plant at an IC50 value of 22 nM.
Yoshiya Seto; Kosaku Takahashi; Hideyuki Matsuura; Yasunori Kogami; Hiroshi Yada; Teruhiko Yoshihara; Kensuke Nabeta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  71     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-09-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1470-5     Citation Subset:  IM    
Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Japan.
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MeSH Terms
Antifungal Agents / pharmacology*
Cladosporium / drug effects
Fungi / chemistry*
Molecular Structure
Peptides, Cyclic / chemistry*,  isolation & purification,  pharmacology*
Phleum / microbiology
Plant Diseases / microbiology
Spores / drug effects
Reg. No./Substance:
0/Antifungal Agents; 0/Peptides, Cyclic; 0/epichlicin

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