Document Detail

Novel contrast mechanisms at 3 Tesla and 7 Tesla.
MedLine Citation:
PMID:  18850506     Owner:  NLM     Status:  MEDLINE    
Osteoarthritis (OA) is the most common musculoskeletal degenerative disease, affecting millions of people. Although OA has been considered primarily a cartilage disorder associated with focal cartilage degeneration, it is accompanied by well-known changes in subchondral and trabecular bone, including sclerosis and osteophyte formation. The exact cause of OA initiation and progression remains under debate, but OA typically first affects weightbearing joints such as the knee. Magnetic resonance imaging (MRI) has been recognized as a potential tool for quantitative assessment of cartilage abnormalities due to its excellent soft tissue contrast. Over the last two decades, several new MR biochemical imaging methods have been developed to characterize the disease process and possibly predict the progression of knee OA. These new MR biochemical methods play an important role not only for diagnosis of disease at an early stage, but also for their potential use in monitoring outcome of various drug therapies (success or failure). Recent advances in multicoil radiofrequency technology and high field systems (3 T and above) significantly improve the sensitivity and specificity of imaging studies for the diagnosis of musculoskeletal disorders. The current state-of-the-art MR imaging methods are briefly reviewed for the quantitative biochemical and functional imaging assessment of musculoskeletal systems.
Ravinder R Regatte; Mark E Schweitzer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2008-10-10
Journal Detail:
Title:  Seminars in musculoskeletal radiology     Volume:  12     ISSN:  1089-7860     ISO Abbreviation:  Semin Musculoskelet Radiol     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-13     Completed Date:  2009-01-02     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  9717520     Medline TA:  Semin Musculoskelet Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  266-80     Citation Subset:  IM    
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MeSH Terms
Cartilage, Articular / pathology
Contrast Media / diagnostic use*
Image Enhancement / methods*
Imaging, Three-Dimensional / methods
Magnetic Resonance Imaging / instrumentation,  methods*
Musculoskeletal Diseases / diagnosis*
Sensitivity and Specificity
Grant Support
Reg. No./Substance:
0/Contrast Media

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