| Novel compound SK-1009 suppresses IL-6 expression through modulation of activation of NF-kappaB pathway. | |
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MedLine Citation:
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PMID: 23018603 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Although interleukin-6 (IL-6) is an important biological mediator playing an indispensable role in inflammation and cancer, few inhibitors and suppressors are known. In the present study, the underlying mechanisms of a novel chemically synthesized compound SK-1009, which has suppressive properties on IL-6 production in human macrophage cells, were examined. SK-1009 suppressed IL-6 mRNA levels in human colon cancer cells. Thus, the influence of SK-1009 on transcription factor, NF-κB, which is involved in expression of the IL-6 gene was assessed. SK-1009 was found to suppress degradation of I-κB, an NF-κB inhibitory factor, and consequently inhibited the NF-κB activation pathway. The inhibitory property was almost the same as other NF-κB inhibitors, such as 5HPP-33. Thus, SK-1009 exerts a potent inhibitory effect on IL-6 expression, apparently mediated by modulation of activation of NF-κB transcription factor. |
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Authors:
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Misato Shimura; Masafumi Yamamoto; Gen Fujii; Mami Takahashi; Masami Komiya; Nobuharu Noma; Sei-Ichi Tanuma; Akinori Yanaka; Michihiro Mutoh |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-27 |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: - ISSN: 1347-5215 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Cancer Prevention Research, National Cancer Center Research Institute. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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