Document Detail

Novel clinical and serological aspects in non-allergic asthma.
MedLine Citation:
PMID:  17884421     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We have recently observed that skin reactivity to autologous serum injection is common in patients with non-allergic asthma. However, clinical significance of skin reactivity to autologous serum remains to be defined. OBJECTIVE: To evaluate the possible relation between skin reactivity to autologous serum and clinical and laboratory characteristics in a series of patients with non-allergic asthma. METHODS: Fifty-five patients with non-allergic asthma underwent in vivo autologous serum skin test (ASST) and in vitro basophil histamine release assay using basophils from a normal donor. Clinical and laboratory characteristics including peripheral blood eosinophilia, antinuclear antibodies and total IgE concentration were evaluated. As control, ASST was performed in 10 allergic asthmatic patients, 10 patients with allergic rhinitis and 10 normal subjects. RESULTS: ASST was positive in 29/55 non-allergic asthmatics (53%), whereas it was negative in all 30 control subjects (P<0.001). The sera of 6 out of 51 patients induced in vitro histamine release from autologous basophils. The sera from two patients induced histamine release from membrane IgE-stripped basophils. A significant predominance of female sex (83%) and a high incidence of antinuclear antibodies (ANA) positivity (55%) were found among ASST-positive patients. CONCLUSION: These findings indicate that ASST is positive in about half patients with non-allergic asthma and that a proportion of patients (16%) has functional evidence of circulating histamine-releasing factors. In addition, predominance of female sex and frequent ANA positivity are in line with an autoimmune basis of non-allergic asthma.
A L Comi; A Tedeschi; M Lorini; A Miadonna
Publication Detail:
Type:  Journal Article     Date:  2007-09-19
Journal Detail:
Title:  Respiratory medicine     Volume:  101     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-10-30     Completed Date:  2008-02-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  2526-33     Citation Subset:  IM    
Divisione di Medicina Interna e Pneumologia, Ospedale Fatebenefratelli, Corso di Porta Nuova, Milano, Italy.
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MeSH Terms
Antibodies, Antinuclear / blood
Asthma / immunology*
Autoimmune Diseases / immunology*
Basophils / immunology
Case-Control Studies
Histamine Release
Hypersensitivity, Immediate / immunology
Immunoglobulin E / blood
Immunologic Tests
Middle Aged
Rhinitis, Allergic, Seasonal / immunology
Serum / immunology
Skin / immunology*
Skin Tests
Transplantation, Autologous
Reg. No./Substance:
0/Antibodies, Antinuclear; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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