| Novel cholic acid functionalized star oligo/poly(DL-lactide)s for biomedical applications. | |
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MedLine Citation:
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PMID: 17245744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Novel cholic acid functionalized star oligo/poly(DL-lactide)s with different molecular weights were synthesized through the ring-opening polymerization of DL-lactide initiated by cholic acid. Compared with poly(DL-lactide), these star oligo/poly(DL-lactide)s show faster hydrolytic degradation rates, and the degradation mechanism changes from bulk erosion to surface erosion with decreasing molecular weight. Based on the specific physicochemical properties of the novel star oligo/poly(DL-lactide), the drug delivery system with submicron size was fabricated using a very convenient "ultrasonic dispersion method" which did not involve toxic organic solvents. The in vitro drug release was studied. |
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Authors:
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Tao Zou; Si-Xue Cheng; Xian-Zheng Zhang; Ren-Xi Zhuo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical materials research. Part B, Applied biomaterials Volume: 82 ISSN: 1552-4973 ISO Abbreviation: J. Biomed. Mater. Res. Part B Appl. Biomater. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-12 Completed Date: 2007-10-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234238 Medline TA: J Biomed Mater Res B Appl Biomater Country: United States |
Other Details:
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Languages: eng Pagination: 400-7 Citation Subset: IM |
Affiliation:
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Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cholic Acid
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chemistry* Drug Delivery Systems* Particle Size Polyesters / chemical synthesis, chemistry* Prednisone / administration & dosage Ultrasonics |
| Chemical | |
Reg. No./Substance:
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0/Polyesters; 26969-66-4/poly(lactide); 53-03-2/Prednisone; 81-25-4/Cholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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