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Novel cellular markers in breast cancer.
MedLine Citation:
PMID:  21541567     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Epidemiological studies have revealed that Parsi women have a higher incidence of breast cancer than non-Parsis and that they are more susceptible to breast cancer. We have studied the cellular distribution of two prosomal proteins p23K in parallel to the p30.33K and proliferation marker Ki-67 as potential markers to identify high risk population for breast cancers. Flow cytometry data demonstrated that the Parsi benign and non-Parsi malignants have a higher number of cells labelled with these two prosomal protein antibodies than the non-Parsi benign and European 'normals'. Using immunohistochemical methods, p23 K was found to be significantly higher in Parsi and non-Parsi malignants as well as in non-Parsi benigns. In our FCM analysis, intergroup comparison showed, interestingly, a significantly higher expression of both p23K and p30.33K in Parsi benigns as compared to non-Parsis, raising the possibility that benign tumors of Parsis represent already premalignant lesions. The present study, in addition, proposes the prosomal antigens as likely cell proliferation markers comparable to Ki-67.
Authors:
A Bhui; J Bureau; A Abbas; A Mondal; K Scherrer; A Kurkure; A Therwath
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of oncology     Volume:  9     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  2011-05-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  669-77     Citation Subset:  -    
Affiliation:
UNIV PARIS 07,ONCOL MOL LAB,F-75005 PARIS,FRANCE. FAC MED NIMES,LAB BIOL CELLULAIRE & IMMUNOGENET,NIMES,FRANCE. CNRS,INST JACQUES MONOD,LAB BIOCHIM DIFFERENTIAT,PARIS,FRANCE. UNIV PARIS 07,F-75005 PARIS,FRANCE. BREACH CANDY HOSP & RES CTR,BOMBAY 400026,MAHARASHTRA,INDIA.
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