Document Detail


Novel biomarkers of prenatal methamphetamine exposure in human meconium.
MedLine Citation:
PMID:  19125148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Meconium analysis can detect fetal exposure to drugs taken by the mother during pregnancy. Methamphetamine (MAMP) and amphetamine (AMP) have previously been observed in meconium of MAMP-exposed neonates; the presence of other metabolites has not been investigated. Detection of such analytes may lead to more sensitive identification and thus improved medical treatment of affected infants. Forty-three MAMP-positive meconium specimens were analyzed for newly identified MAMP biomarkers, p-hydroxymethamphetamine, p-hydroxyamphetamine, and norephedrine. Due to MAMP adulteration in illicit ecstasy and to simultaneously monitor 3,4-methylenedioxymethamphetamine and MAMP prenatal exposure, 3,4-methylenedioxymethamphetamine, its metabolites, and related sympathomimetic amines were assayed. MAMP, AMP, and unconjugated p-hydroxymethamphetamine were the most prevalent and abundant analytes present in meconium; however, unconjugated p-hydroxyamphetamine and norephedrine also were identified. It is possible that one of these additional analytes could be important for predicting toxicity or maternal or neonatal outcome measures in fetuses exposed to MAMP at specific gestational ages or with different metabolic capabilities. Although these new biomarkers were present in lower concentrations than MAMP and AMP in the meconium of previously confirmed specimens, additional research will determine if inclusion of these analytes can increase identification of MAMP-exposed neonates. Novel methamphetamine biomarker concentrations were characterized in meconium of infants exposed in utero to MAMP.
Authors:
Teresa R Gray; Tamsin Kelly; Linda L LaGasse; Lynne M Smith; Chris Derauf; William Haning; Penny Grant; Rizwan Shah; Amelia Arria; Arthur Strauss; Barry M Lester; Marilyn A Huestis
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Therapeutic drug monitoring     Volume:  31     ISSN:  1536-3694     ISO Abbreviation:  Ther Drug Monit     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-03-12     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  7909660     Medline TA:  Ther Drug Monit     Country:  United States    
Other Details:
Languages:  eng     Pagination:  70-5     Citation Subset:  IM    
Affiliation:
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers
Biotransformation
Central Nervous System Stimulants / pharmacokinetics*
Chromatography, High Pressure Liquid
Female
Gestational Age
Humans
Infant, Newborn
Mass Spectrometry
Meconium / chemistry*
Methamphetamine / pharmacokinetics*
Pregnancy
Pregnancy Outcome
Sympathomimetics / analysis
Young Adult
Grant Support
ID/Acronym/Agency:
Z01 DA000433-08/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Central Nervous System Stimulants; 0/Sympathomimetics; 537-46-2/Methamphetamine
Comments/Corrections

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