| Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T. | |
| | |
MedLine Citation:
|
PMID: 18682444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: To evaluate the role of novel biomarkers in early detection of acute myocardial infarction (MI) in patients admitted with acute chest pain. METHODS AND RESULTS: A prospective study of 664 patients presenting to two coronary care units with chest pain was conducted over 3 years from 2003. Patients were assessed on admission: clinical characteristics, ECG (electrocardiogram), renal function, cardiac troponin T (cTnT), heart fatty acid binding protein (H-FABP), glycogen phosphorylase-BB, NT-pro-brain natriuretic peptide, D-dimer, hsCRP (high sensitivity C-reactive protein), myeloperoxidase, matrix metalloproteinase-9, pregnancy associated plasma protein-A, soluble CD40 ligand. A > or = 12 h cTnT sample was also obtained. MI was defined as cTnT > or = 0.03 microg/L. In patients presenting <4 h of symptom onset, sensitivity of H-FABP for MI was significantly higher than admission cTnT (73 vs. 55%; P = 0.043). Specificity of H-FABP was 71%. None of the other biomarkers challenged cTnT. Combined use of H-FABP and cTnT (either one elevated initially) significantly improved the sensitivities of H-FABP or cTnT (85%; P < or = 0.004). This combined approach also improved the negative predictive value, negative likelihood ratio, and the risk ratio. CONCLUSION: Assessment of H-FABP within the first 4 h of symptoms is superior to cTnT for detection of MI, and is a useful additional biomarker for patients with acute chest pain. |
| | |
Authors:
|
Conor J McCann; Ben M Glover; Ian B A Menown; Michael J Moore; Jane McEneny; Colum G Owens; Bernie Smith; Peter C Sharpe; Ian S Young; Jennifer A Adgey |
Related Documents
:
|
9226044 - Myocardial bridging as a factor in heart disorders: critical review and hypothesis. 7221404 - Creatine kinase and myoglobin determination in myocardial infarction (determination of ... 21237604 - Can left ventricular end-diastolic volumes be estimated with prospective ecg-gated ct c... 7614544 - Safety of coronary ultrasound angioplasty: effects of sonication on intact canine coron... 17966554 - Superior biatrial septotomy and beating heart approach for aortic and mitral valve repl... 7883664 - Evaluation of apolipoproteins a1 and b in survivors of myocardial infarction. |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2008-08-05 |
Journal Detail:
|
Title: European heart journal Volume: 29 ISSN: 1522-9645 ISO Abbreviation: Eur. Heart J. Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-12-02 Completed Date: 2009-02-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
|
Languages: eng Pagination: 2843-50 Citation Subset: IM |
Affiliation:
|
The Heart Centre, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angina, Unstable
/
diagnosis* Biological Markers / metabolism Chest Pain / etiology Electrocardiography Epidemiologic Methods Fatty Acid-Binding Proteins / metabolism* Female Humans Male Middle Aged Myocardial Infarction / diagnosis* Natriuretic Peptide, Brain / metabolism* Prognosis Troponin T / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/FABP3 protein, human; 0/Fatty Acid-Binding Proteins; 0/Troponin T; 114471-18-0/Natriuretic Peptide, Brain |
| Comments/Corrections | |
Comment In:
|
Eur Heart J. 2008 Dec;29(23):2827-8
[PMID:
18957473
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: REM sleep behaviour disorder in Parkinson's disease is associated with specific motor features.
Next Document: Reduction in recurrent cardiovascular events with prasugrel compared with clopidogrel in patients wi...