| Novel baroreflex activation therapy in resistant hypertension: results of a European multi-center feasibility study. | |
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MedLine Citation:
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PMID: 20883933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: This study assessed the safety and efficacy of a novel implantable device therapy in resistant hypertension patients. BACKGROUND: Despite the availability of potent antihypertensive drugs, a substantial proportion of patients remain hypertensive. A new implantable device (Rheos system, CVRx, Inc., Minneapolis, Minnesota) that activates the carotid baroreflex may help these patients. METHODS: Forty-five subjects with systolic blood pressure ≥160 mm Hg or diastolic ≥90 mm Hg despite at least 3 antihypertensive drugs were enrolled in a prospective, nonrandomized feasibility study to assess whether Rheos therapy could safely lower blood pressure. Subjects were followed up for as long as 2 years. An external programmer was used to optimize and individualize efficacy. RESULTS: Baseline mean blood pressure was 179/105 mm Hg and heart rate was 80 beats/min, with a median of 5 antihypertensive drugs. After 3 months of device therapy, mean blood pressure was reduced by 21/12 mm Hg. This result was sustained in 17 subjects who completed 2 years of follow-up, with a mean reduction of 33/22 mm Hg. The device exhibited a favorable safety profile. CONCLUSIONS: The Rheos device sustainably reduces blood pressure in resistant hypertensive subjects with multiple comorbidities receiving numerous medications. This unique therapy offers a safe individualized treatment option for these high-risk subjects. This novel approach holds promise for patients with resistant hypertension and is currently under evaluation in a prospective, placebo-controlled clinical trial. |
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Authors:
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Ingrid J M Scheffers; Abraham A Kroon; Jürg Schmidli; Jens Jordan; Jan J M Tordoir; Markus G Mohaupt; Friedrich C Luft; Hermann Haller; Jan Menne; Stefan Engeli; Jiri Ceral; Siegfried Eckert; Andrejs Erglis; Krzysztof Narkiewicz; Thomas Philipp; Peter W de Leeuw |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 56 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-10-22 Revised Date: 2012-05-29 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1254-8 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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University Hospital Maastricht and Cardiovascular Research Institute Maastricht (CARIM), Maastricht, the Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Baroreflex / physiology* Electric Stimulation Therapy / instrumentation*, methods Europe / epidemiology Feasibility Studies Female Follow-Up Studies Humans Hypertension / epidemiology, physiopathology*, therapy* Male Middle Aged Prospective Studies Treatment Outcome |
| Comments/Corrections | |
Comment In:
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Auton Neurosci. 2012 Jan 26;166(1-2):1-3
[PMID:
22137183
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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