Document Detail

Novel autoantibodies against 7SL RNA in patients with polymyositis/dermatomyositis.
MedLine Citation:
PMID:  16142868     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Autoantibodies against signal recognition particle (SRP) are detected in patients with polymyositis/dermatomyositis (PM/DM). The SRP consists of 7SL RNA and 6 protein components. We examined autoantibodies against deproteinized 7SL RNA in PM/DM patients with anti-SRP antibodies and evaluated the association of anti-7SL RNA antibodies with PM/DM clinically and serologically. METHODS: Sera from 10 Japanese and 22 North American PM/DM patients with anti-SRP antibodies were tested for the presence of anti-7SL RNA antibodies, using the sera to immunoprecipitate deproteinized RNA extracts derived from HeLa cells. RESULTS: The immunoprecipitation analysis indicated that 5 Japanese (50%) and one North American (5%) patient with anti-SRP antibodies had novel autoantibodies against deproteinized 7SL RNA. The frequency of anti-7SL RNA antibodies was significantly higher in Japanese than North American patients (p = 0.006). The presence of anti-7SL RNA antibodies appeared to be associated with DM (2 patients) and finger swelling (2 PM patients). The seasonal onset of the disease was different (p = 0.008) for Japanese PM/DM patients with anti-7SL RNA antibodies, who developed the disease between October and January (mean month November; p = 0.01) from that of patients without these antibodies, who developed it between June and August (mean month July; p = 0.01). CONCLUSION: Novel autoantibodies against 7SL RNA were identified in patients with PM/DM, and the presence of these antibodies was correlated to ethnic background, clinical features, and season of disease onset. These findings indicated that autoantibodies against 7SL RNA are a novel serological marker for a subset of PM/DM cases.
Takashi Satoh; Tetsuroh Okano; Toshimichi Matsui; Hiroyuki Watabe; Takashi Ogasawara; Kouya Kubo; Masataka Kuwana; Noreen Fertig; Chester V Oddis; Hirobumi Kondo; Tohru Akahoshi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  32     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-05     Completed Date:  2005-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1727-33     Citation Subset:  IM    
Department of Laboratory Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
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MeSH Terms
Asian Continental Ancestry Group*
Autoantibodies / analysis,  immunology*
Biological Markers
Cohort Studies
Dermatomyositis / blood,  ethnology,  immunology
European Continental Ancestry Group*
Follow-Up Studies
Middle Aged
Polymyositis / blood,  ethnology*,  immunology*
RNA, Small Cytoplasmic / analysis,  immunology*
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Signal Recognition Particle / analysis,  immunology*
Reg. No./Substance:
0/7SL RNA; 0/Autoantibodies; 0/Biological Markers; 0/RNA, Small Cytoplasmic; 0/Signal Recognition Particle

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