| Novel aspects of fibrin(ogen) fragments in the course of inflammation. | |
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MedLine Citation:
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PMID: 21210072 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Coagulation is a constant attendant of inflammation and is fundamental for the confinement of infection and/or the inflammatory response to a limited area. Under pathological inflammatory conditions such as arthritis, multiple sclerosis or sepsis an uncontrolled activation of the coagulation system contributes to inflammation, microvascular failure and organ dysfunction. Coagulation is initiated by the activation of thrombin which in turn by the release of fibrinopeptides, triggers fibrin formation. Fibrin is cleaved by plasmin resulting in clot lysis and accompanied generation of fibrin fragments such as D and E fragments. Various coagulation factors including fibrin(ogen) and also fibrin degradation products modulate the inflammatory response by affecting leukocyte migration and cytokine production. Fibrin fragments are mostly pro-inflammatory, however, Bβ15-42 in particular possesses potential anti-inflammatory effects. Bβ15-42 inhibits Rho kinase activation by dissociating Fyn from Rho and, hence prevents stress-induced loss of endothelial barrier function and also leukocyte migration. This article summarizes state of the art of inflammatory modulation by fibrin(ogen) and fibrin fragments. However, further research is required to gain better understanding of the entire role, fibrin fragments play during inflammation and possibly disease development. |
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Authors:
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Carla Jennewein; Nguyen Tran; Patrick Paulus; Peter Ellinghaus; Johannes Andreas Eble; Kai Zacharowski |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-4 |
Journal Detail:
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Title: Molecular medicine (Cambridge, Mass.) Volume: - ISSN: 1528-3658 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9501023 Medline TA: Mol Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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