Document Detail


Novel approaches for the treatment of food allergy.
MedLine Citation:
PMID:  12045426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
At present there is no effective therapy for IgE-mediated food allergy, and patients must rely upon food-allergen avoidance. Unfortunately, the accidental ingestion of allergen-containing foods leading to potentially severe reactions is common. Definitive therapies for food allergy are desperately needed. Although rush immunotherapy has been reported to induce tolerance in some patients, the rate of maintenance of tolerance was low, and there was an undesirably high incidence of adverse reactions. New knowledge of the immunological mechanisms underlying allergic disease has expanded the potential therapeutic options for food allergy. The establishment of animal models of food hypersensitivity, which include sensitization by the oral route and anaphylaxis upon oral challenge, have facilitated the investigation of therapies for food allergy. Novel approaches under investigation include the reduction of IgE by the infusion of anti-IgE antibodies, vaccination with plasmid DNA, the use of anti-allergy immunostimulatory sequences, cytokines and bacterial agents, immunotherapy with mutated proteins and peptides, and complementary medicine such as Chinese herbs.
Authors:
Xiu-Min Li; Hugh A Sampson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  2     ISSN:  1528-4050     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-04     Completed Date:  2002-10-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-8     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029-6574, USA. xiu-min.li@mssm.edu
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MeSH Terms
Descriptor/Qualifier:
Antibody Specificity / immunology
Desensitization, Immunologic
Food Hypersensitivity / immunology*,  therapy*
Humans
Immunoglobulin E / immunology,  therapeutic use
Milk Proteins / adverse effects*
United States
Chemical
Reg. No./Substance:
0/Milk Proteins; 37341-29-0/Immunoglobulin E

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