| Novel approaches for inhibition of mucus hypersecretion in asthma. | |
| | |
MedLine Citation:
|
PMID: 19075982 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Many obstructive airway disorders such as cystic fibrosis, asthma, and chronic obstructive pulmonary disease (COPD) are characterized by mucous metaplasia of the airway epithelium and chronic mucus hypersecretion. Airway occlusion by mucus plugging has been reported in many cases of fatal asthma and conventional mucolytic therapies have been unable to significantly affect mucus-related airway obstruction. Recently, for the first time, direct evidence was presented for improvement of mucus related airway obstruction in a murine model of asthma, highlighting the potential usefulness of therapeutically targeting mucus hypersecretion. We review the emerging targets for inhibition of mucus hypersecretion and discuss some of the recent published scientific literature and patent applications in this field, to provide a framework for further drug discovery in mucus modulation. |
| | |
Authors:
|
Anurag Agrawal; Ulaganathan Mabalirajan; Arjun Ram; Balaram Ghosh |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Recent patents on inflammation & allergy drug discovery Volume: 1 ISSN: 1872-213X ISO Abbreviation: Recent Pat Inflamm Allergy Drug Discov Publication Date: 2007 Nov |
Date Detail:
|
Created Date: 2008-12-16 Completed Date: 2009-02-26 Revised Date: 2011-06-17 |
Medline Journal Info:
|
Nlm Unique ID: 101309297 Medline TA: Recent Pat Inflamm Allergy Drug Discov Country: United Arab Emirates |
Other Details:
|
Languages: eng Pagination: 188-92 Citation Subset: IM |
Affiliation:
|
Molecular Immunology and Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, University of Delhi, Delhi-110 007, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Airway Obstruction
/
etiology,
metabolism,
prevention & control* Animals Anti-Asthmatic Agents / therapeutic use* Anti-Inflammatory Agents / therapeutic use* Asthma / complications, drug therapy*, metabolism Elasticity Exocytosis / drug effects Expectorants / therapeutic use* Goblet Cells / drug effects*, enzymology, secretion Humans Mucus / chemistry, secretion* Patents as Topic Signal Transduction / drug effects Viscosity |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Asthmatic Agents; 0/Anti-Inflammatory Agents; 0/Expectorants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Potential of lung surfactant proteins, SP-A and SP-D, and mannan binding lectin for therapy and gene...
Next Document: Biologic agents in the treatment of psoriasis.