Document Detail


Novel approaches for inhibition of mucus hypersecretion in asthma.
MedLine Citation:
PMID:  19075982     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many obstructive airway disorders such as cystic fibrosis, asthma, and chronic obstructive pulmonary disease (COPD) are characterized by mucous metaplasia of the airway epithelium and chronic mucus hypersecretion. Airway occlusion by mucus plugging has been reported in many cases of fatal asthma and conventional mucolytic therapies have been unable to significantly affect mucus-related airway obstruction. Recently, for the first time, direct evidence was presented for improvement of mucus related airway obstruction in a murine model of asthma, highlighting the potential usefulness of therapeutically targeting mucus hypersecretion. We review the emerging targets for inhibition of mucus hypersecretion and discuss some of the recent published scientific literature and patent applications in this field, to provide a framework for further drug discovery in mucus modulation.
Authors:
Anurag Agrawal; Ulaganathan Mabalirajan; Arjun Ram; Balaram Ghosh
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Recent patents on inflammation & allergy drug discovery     Volume:  1     ISSN:  1872-213X     ISO Abbreviation:  Recent Pat Inflamm Allergy Drug Discov     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-02-26     Revised Date:  2011-06-17    
Medline Journal Info:
Nlm Unique ID:  101309297     Medline TA:  Recent Pat Inflamm Allergy Drug Discov     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  188-92     Citation Subset:  IM    
Affiliation:
Molecular Immunology and Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, University of Delhi, Delhi-110 007, India.
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MeSH Terms
Descriptor/Qualifier:
Airway Obstruction / etiology,  metabolism,  prevention & control*
Animals
Anti-Asthmatic Agents / therapeutic use*
Anti-Inflammatory Agents / therapeutic use*
Asthma / complications,  drug therapy*,  metabolism
Elasticity
Exocytosis / drug effects
Expectorants / therapeutic use*
Goblet Cells / drug effects*,  enzymology,  secretion
Humans
Mucus / chemistry,  secretion*
Patents as Topic
Signal Transduction / drug effects
Viscosity
Chemical
Reg. No./Substance:
0/Anti-Asthmatic Agents; 0/Anti-Inflammatory Agents; 0/Expectorants

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