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Novel approaches in the treatment of myositis and myopathies.
MedLine Citation:
PMID:  23024713     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The inflammatory myopathies are a heterogeneous group of disorders characterized by muscle weakness and inflammation. Although no standard therapeutic guidelines exist, traditional treatment has included corticosteroids and a variety of second-line immunosuppressants. As treatment of refractory disease has been difficult, newer agents and approaches have been used with varying response. The advent of standardized treatment response criteria by the International Myositis Assessment and Clinical Studies (IMACS) group has helped investigators to evaluate and compare clinical trial outcomes in a more rigorous fashion. The use of intravenous immunoglobulin (IVIG), rituximab, biologic agents including tumor necrosis factor (TNF) inhibitors, stem-cell transplantation, gene therapy, and vascular occlusion resistance training are reviewed here. As our understanding of disease pathogenesis at the immunologic, genetic, and molecular level expands, the discovery of novel therapeutic targets hold promise for the successful treatment of these conditions.
Authors:
Jemima Albayda; Lisa Christopher-Stine
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic advances in musculoskeletal disease     Volume:  4     ISSN:  1759-7218     ISO Abbreviation:  Ther Adv Musculoskelet Dis     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2012-10-02     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101517322     Medline TA:  Ther Adv Musculoskelet Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  369-77     Citation Subset:  -    
Affiliation:
Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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