Document Detail


Novel approaches in the treatment of multiple myeloma.
MedLine Citation:
PMID:  14582216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite all the new advances, treatment of multiple myeloma remains very challenging. Table 6 summarizes the outcomes of some of the commonly used treatments from different clinical trails. Treatment with conventional chemotherapy alone resulted in median survival from 18 to 30 months. Aggressive treatments like VBMCP (vincristine, bleomycin, melphalan, cyclophosphamide, predisone) although resulting in higher response rates, resulted in higher treatment-related mortality and did not have any effect on median and 5 year survival. High dose chemotherapy with stem cell support increased the median survival to around 60 months and resulted in durable complete responses in a significant number of the patients. Some of the newer and promising treatments for multiple myeloma are summarized in Table 7.
Authors:
Mehrdad Abedi; Gerald J Elfenbein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Medicine and health, Rhode Island     Volume:  86     ISSN:  1086-5462     ISO Abbreviation:  Med Health R I     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-10-29     Completed Date:  2003-12-29     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  9603446     Medline TA:  Med Health R I     Country:  United States    
Other Details:
Languages:  eng     Pagination:  231-5     Citation Subset:  IM    
Affiliation:
Boston University School of Medicine, USA.mabedi@rwmc.org
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Humans
Multiple Myeloma / diagnosis,  etiology,  therapy*
Neoplasm Staging
Prognosis
Stem Cell Transplantation

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