Document Detail

Novel approach to the eradication of Pseudomonas aeruginosa in an infant with CF after outpatient treatment failure.
MedLine Citation:
PMID:  18383117     Owner:  NLM     Status:  MEDLINE    
Intravenous continuous infusion of betalactam (CIBL) antibiotic and high dose extended interval (HDEI) aminoglycoside therapy theoretically maximize bacterial killing in treatment of Pseudomonas aeruginosa (PsA) in pulmonary exacerbations of cystic fibrosis (CF). We present the case of a 3-month-old female infant with CF who failed outpatient eradication of PsA with subsequent eradication using intravenous CIBL antibiotic and HDEI aminoglycoside therapy. This antibiotic combination should be considered in order to optimize pharmacodynamics for PsA eradication in CF patients before development of chronic colonization.
Don Hayes; Jamshed F Kanga; Michael I Anstead; Robert J Kuhn
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  43     ISSN:  1099-0496     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-03     Completed Date:  2008-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  511-3     Citation Subset:  IM    
Copyright Information:
Copyright 2008 Wiley-Liss, Inc.
Departments of Pediatrics and Internal Medicine, University of Kentucky College of Medicine, J410 Kentucky Clinic, 740 South Limestone Street, Lexington, Kentucky 40536, USA.
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MeSH Terms
Aminoglycosides / administration & dosage,  therapeutic use*
Anti-Bacterial Agents / administration & dosage,  therapeutic use*
Area Under Curve
Cystic Fibrosis / microbiology*
Dose-Response Relationship, Drug
Drug Therapy, Combination
Infusions, Intravenous
Pseudomonas Infections / drug therapy*
Pseudomonas aeruginosa / drug effects*,  isolation & purification
Treatment Failure
Treatment Outcome
beta-Lactams / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 0/beta-Lactams

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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