Document Detail

Novel antizyme gene in Danio rerio expressed in brain and retina.
MedLine Citation:
PMID:  17049757     Owner:  NLM     Status:  MEDLINE    
The synthesis of the protein antizyme requires a +1 ribosomal frameshift event. The frameshifting serves as a regulatory sensor. Antizyme homologs have been identified in diverse organisms ranging from yeast to human and characterized in a disparate subset. Most vertebrates have multiple antizyme paralogs. Here we present identification in the zebrafish Danio rerio of a heretofore unknown member of the antizyme gene family. This novel antizyme does not correspond to any of the known orthologous groups in vertebrates and unlike most other antizymes is preferentially expressed in the retinal ganglion cell layer of the eye. In addition to the retina, it is also expressed in the brain and somites.
Ivaylo P Ivanov; Andrew J Pittman; Chi-Bin Chien; Raymond F Gesteland; John F Atkins
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-08-30
Journal Detail:
Title:  Gene     Volume:  387     ISSN:  0378-1119     ISO Abbreviation:  Gene     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-06-26     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7706761     Medline TA:  Gene     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  IM    
Department of Human Genetics, University of Utah, Utah 84112-5330, United States.
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MeSH Terms
Amino Acid Sequence
Brain / metabolism*
Enzyme Inhibitors / metabolism*
Gene Expression Regulation, Developmental
Molecular Sequence Data
Ornithine Decarboxylase / antagonists & inhibitors*
Protein Biosynthesis
Proteins / genetics,  metabolism*
Retina / metabolism*
Zebrafish / embryology,  genetics,  metabolism*
Grant Support
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Proteins; 0/ornithine decarboxylase antizyme; EC Decarboxylase

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