Document Detail


Novel anticonvulsants in the treatment of alcoholism.
MedLine Citation:
PMID:  15882114     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There have been many recent developments in the pharmacological management of alcohol withdrawal and alcohol dependence. Although previous treatments had included benzodiazepines as their mainstay, the use of these agents in the alcoholic population is problematic. Benzodiazepines are themselves addictive and they may increase the risk of alcohol relapse. Non-benzodiazepine anticonvulsants such as carbamazepine, valproic acid, gabapentin, vigabatrin and topiramate have been shown to be excellent treatments of both alcohol withdrawal and the prevention of alcohol relapse. Although none of these agents have yet been approved by the FDA, there is growing evidence in the literature to support their use.
Authors:
Sarah W Book; Hugh Myrick
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Expert opinion on investigational drugs     Volume:  14     ISSN:  1744-7658     ISO Abbreviation:  Expert Opin Investig Drugs     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-05-10     Completed Date:  2006-11-14     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  9434197     Medline TA:  Expert Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  371-6     Citation Subset:  IM    
Affiliation:
Medical University of South Carolina, Department of Psychiatry and Behavioural Sciences, Charleston Alcohol Research Center, 67 President Street, Charleston, SC 29425, USA. booksw@musc.edu
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MeSH Terms
Descriptor/Qualifier:
Alcohol Deterrents / therapeutic use
Alcoholism / drug therapy*,  prevention & control
Amines / therapeutic use
Anticonvulsants / therapeutic use*
Carbamazepine / therapeutic use
Cyclohexanecarboxylic Acids / therapeutic use
Ethanol / adverse effects*
Humans
Randomized Controlled Trials as Topic
Recurrence / prevention & control
Substance Withdrawal Syndrome / drug therapy*
Valproic Acid / therapeutic use
gamma-Aminobutyric Acid / therapeutic use
Grant Support
ID/Acronym/Agency:
2 P50 AA10761-03/AA/NIAAA NIH HHS; K23 AA00314-01/AA/NIAAA NIH HHS; K23 AA014430/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Alcohol Deterrents; 0/Amines; 0/Anticonvulsants; 0/Cyclohexanecarboxylic Acids; 298-46-4/Carbamazepine; 56-12-2/gamma-Aminobutyric Acid; 64-17-5/Ethanol; 6CW7F3G59X/gabapentin; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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