| [Novel anticoagulants for stroke prevention in atrial fibrillation]. | |
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MedLine Citation:
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PMID: 21064013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The most frequent cardiac arrhythmia and main cause for cardio-embolic stroke is atrial fibrillation. Prophylaxis for thrombembolic events is performed regarding individual risk of patients with either ASS or vitamin-K-antagonists. Efficacy and safety of oral anticoagulation is limited by a narrow therapeutical range as well as by inter- and intraindividual variability of INR-values due to genetic disposition, differences in alimentation, dosage errors, rare control of INR-levels and drug-interactions. New oral anticoagulants with different mechanisms of action may be a promising therapeutic option in future. This review addresses the new anticoagulants Apixaban, Rivaroxban and Dabigatranetexilat with the design and as available the results of the corresponding phase-III-trials in atrial fibrillation (ARISTOTLE, ROCKET-AF, RE-LY). |
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Authors:
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M Baumhäkel; S H Schirmer; M Böhm |
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Publication Detail:
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Type: English Abstract; Journal Article; Review Date: 2010-11-09 |
Journal Detail:
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Title: Deutsche medizinische Wochenschrift (1946) Volume: 135 ISSN: 1439-4413 ISO Abbreviation: Dtsch. Med. Wochenschr. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-10 Completed Date: 2010-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0006723 Medline TA: Dtsch Med Wochenschr Country: Germany |
Other Details:
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Languages: ger Pagination: 2304-8 Citation Subset: IM |
Copyright Information:
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© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes. magnus@baumhaekel.de |
Vernacular Title:
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Neue Antikoagulanzien für die Thromboembolieprophylaxe bei Vorhofflimmern. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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classification,
therapeutic use* Antithrombins / therapeutic use Atrial Fibrillation / complications*, drug therapy Azetidines / therapeutic use Benzimidazoles / therapeutic use Benzylamines / therapeutic use Clinical Trials, Phase III as Topic Factor Xa / antagonists & inhibitors Fibrinolytic Agents / classification, therapeutic use* Humans Morpholines / therapeutic use Pyrazoles / therapeutic use Pyridines / therapeutic use Pyridones / therapeutic use Stroke / prevention & control* Thiophenes / therapeutic use Thromboembolism / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Antithrombins; 0/Azetidines; 0/Benzimidazoles; 0/Benzylamines; 0/Fibrinolytic Agents; 0/Morpholines; 0/Pyrazoles; 0/Pyridines; 0/Pyridones; 0/Thiophenes; 0/apixaban; 0/rivaroxaban; 0/ximelagatran; 211915-06-9/dabigatran etexilate; EC 3.4.21.6/Factor Xa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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