| Novel angiotensin II inhibitors in cardiovascular medicine. | |
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MedLine Citation:
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PMID: 11772299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blockade of the renin-angiotensin-aldosterone cascade is now recognised as a very effective approach to treat hypertensive, heart failure and high cardiovascular risk patients and to retard the development of renal failure. The purpose of this review is to discuss the state of development of currently available drugs blocking the renin-angiotensin system, such as angiotensin converting enzyme (ACE) inhibitors, renin inhibitors and angiotensin II receptor antagonists, with a special emphasis on the results of the most recent trials conducted with AT(2) receptor antagonists in heart failure and Type 2 diabetes. In addition, the future perspectives of drugs with dual mechanisms of action, such as NEP/ACE inhibitors, also named vasopeptidase inhibitors, are presented. |
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Authors:
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M Burnier |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on investigational drugs Volume: 10 ISSN: 1354-3784 ISO Abbreviation: Expert Opin Investig Drugs Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2002-01-04 Completed Date: 2002-03-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9434197 Medline TA: Expert Opin Investig Drugs Country: England |
Other Details:
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Languages: eng Pagination: 1957-64 Citation Subset: IM |
Affiliation:
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Division of Hypertension and Vascular Medicine,Av. P. Decker, 1011 Lausanne, Switzerland. Michel.Burnier@chuv.hospvd.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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antagonists & inhibitors*,
metabolism Angiotensin-Converting Enzyme Inhibitors / adverse effects, therapeutic use Animals Cardiovascular Agents / adverse effects, therapeutic use* Cardiovascular Diseases / drug therapy* Clinical Trials as Topic Humans Protease Inhibitors / adverse effects, therapeutic use Receptors, Angiotensin / antagonists & inhibitors Renin / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Cardiovascular Agents; 0/Protease Inhibitors; 0/Receptors, Angiotensin; 11128-99-7/Angiotensin II; EC 3.4.23.15/Renin |
| Comments/Corrections | |
Erratum In:
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Expert Opin Investig Drugs. 2002 Jan;11(1):151 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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