| Novel amino acid modified zinc polycarboxylates for improved dental cements. | |
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MedLine Citation:
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PMID: 15882900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of this study was to develop a novel amino acid modified zinc/calcium polycarboxylate cement system, formulate the cements, and evaluate their mechanical strengths. MATERIALS AND METHODS: Acrylate and methacrylate derivatives of four amino acids were synthesized and characterized using FT-IR and 1HNMR spectroscopy. The derivatives were formulated with polymer having pendent methacrylate group, water, and synthesized novel filler. Compressive (CS) as well as flexural strengths (FS) and viscosities of the resin liquids were used as tools to evaluate the formulations and formed cements. The specimens for CS and FS tests were conditioned in distilled water at 37 degrees C for 24 h and 7 d, respectively, prior to testing. RESULTS: The measured CS and FS of the cements was in the decreasing order of methacryloyl beta-alanine > acryloyl glutamic acid = acryloyl beta-alanine > methacryloyl glutamic acid > 2-hydroxyethyl methacrylate. Methacryloyl beta-alanine was selected for further formulations due to its relatively low solution viscosity and high CS as well as FS. Effects of polymer content, P/L ratio, tartaric acid and initiator concentration were significant. During aging, the cement showed a constant increase in CS for up to 1 month and then kept constant for up to 3 months. CONCLUSIONS: This study developed a novel amino acid modified zinc/calcium polycarboxylate cement system. This system was 85% higher in CS, 98% higher in DTS and 183% higher in FS, compared to Durelon. |
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Authors:
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Dong Xie; Mona Faddah; Jong-Gu Park |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Dental materials : official publication of the Academy of Dental Materials Volume: 21 ISSN: 0109-5641 ISO Abbreviation: Dent Mater Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-07-19 Completed Date: 2005-09-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8508040 Medline TA: Dent Mater Country: England |
Other Details:
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Languages: eng Pagination: 739-48 Citation Subset: D |
Affiliation:
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Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University-Purdue University, Indianapolis, IN 46202, USA. dxie@iupui.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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chemistry* Calcium / chemistry Chemistry, Pharmaceutical Compressive Strength Glutamic Acid / chemistry Humans Magnetic Resonance Spectroscopy Materials Testing Methacrylates / chemistry Pliability Polycarboxylate Cement / chemical synthesis, chemistry* Spectroscopy, Fourier Transform Infrared Stress, Mechanical Tartrates / chemistry Time Factors Viscosity Zinc / chemistry beta-Alanine / chemistry |
| Grant Support | |
ID/Acronym/Agency:
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1R01 EB03162-01/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Methacrylates; 0/Polycarboxylate Cement; 0/Tartrates; 107-95-9/beta-Alanine; 526-83-0/tartaric acid; 56-86-0/Glutamic Acid; 7440-66-6/Zinc; 7440-70-2/Calcium; 868-77-9/hydroxyethyl methacrylate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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