| Novel vitamin and gold-loaded nanofiber facial mask for topical delivery. | |
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MedLine Citation:
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PMID: 20661676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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L-ascorbic acid has been widely used in cosmetic and dermatological products because of its ability to scavenge free radicals and destroy oxidizing agents. However, it is chemically unstable and can easily be oxidized. The current cosmetic facial masks available in the market are pre-moistened, which means that the aqueous fluid content of the mask may oxidize some of the unstable active ingredients such as ascorbic acid. This work presents an anti-wrinkle nanofiber face mask containing ascorbic acid, retinoic acid, gold nanoparticles, and collagen. This novel face mask will only be wetted when applied to the skin, thus enhancing product stability. Once moistened, the content of the mask will gradually dissolve and release the active ingredients and ensure maximum skin penetration. The high surface area-to-volume ratio of the nanofiber mask will ensure maximum contact with the skin surface and help to enhance the skin permeation to restore its healthy appearance. Electrospun fiber mats may provide an attractive alternative to the commercial facial cotton masks. |
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Authors:
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Anahita Fathi-Azarbayjani; Lin Qun; Yew Weng Chan; Sui Yung Chan |
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Publication Detail:
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Type: In Vitro; Journal Article Date: 2010-07-27 |
Journal Detail:
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Title: AAPS PharmSciTech Volume: 11 ISSN: 1530-9932 ISO Abbreviation: AAPS PharmSciTech Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-11-05 Completed Date: 2011-03-07 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 100960111 Medline TA: AAPS PharmSciTech Country: United States |
Other Details:
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Languages: eng Pagination: 1164-70 Citation Subset: IM |
Affiliation:
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Department of Pharmacy, National University of Singapore, Block S4, level 2, Science Drive 4, 117543, Singapore, Singapore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Administration, Topical Ascorbic Acid / administration & dosage*, chemistry* Dermatologic Agents / administration & dosage, chemistry Drug Carriers / chemical synthesis* Gold / chemistry* Humans Masks* Nanostructures / chemistry* Skin / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Dermatologic Agents; 0/Drug Carriers; 50-81-7/Ascorbic Acid; 7440-57-5/Gold |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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