| Novel use of zolpidem in cerebellar mutism syndrome. | |
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MedLine Citation:
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PMID: 21285896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebellar mutism syndrome (CMS) is a complication of posterior fossa surgery seen primarily in pediatric patients after resection of medulloblastoma. CMS is characterized by mutism, ataxia, hypotonia, and irritability. Currently, there is no therapy of proven efficacy. Zolpidem, although primarily used as a sedative, has been shown to alleviate mutism and promote arousal in similar neurologic and psychiatric disorders. Here, we describe a child with severe CMS in whom zolpidem seemed to increase arousal, accelerate the resolution of mutism, and decrease emotional lability. Our report suggests that clinicians should consider using zolpidem for patients with CMS. |
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Authors:
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Charles Shyu; Kelly Burke; Mark M Souweidane; Ira J Dunkel; Stephen W Gilheeney; Timothy Gershon; Yasmin Khakoo |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 33 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-23 Completed Date: 2011-04-08 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 148-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Illinois at Urban-Champaign, New York, NY 10065, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cerebellar Diseases
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drug therapy,
etiology Cerebellar Neoplasms / surgery Child, Preschool Female GABA-A Receptor Agonists / therapeutic use* Humans Medulloblastoma / surgery Mutism / drug therapy*, etiology Neurosurgical Procedures / adverse effects* Postoperative Complications / drug therapy* Pyridines / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/GABA-A Receptor Agonists; 0/Pyridines; 82626-48-0/zolpidem |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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