Document Detail

Novel use of zolpidem in cerebellar mutism syndrome.
MedLine Citation:
PMID:  21285896     Owner:  NLM     Status:  MEDLINE    
Cerebellar mutism syndrome (CMS) is a complication of posterior fossa surgery seen primarily in pediatric patients after resection of medulloblastoma. CMS is characterized by mutism, ataxia, hypotonia, and irritability. Currently, there is no therapy of proven efficacy. Zolpidem, although primarily used as a sedative, has been shown to alleviate mutism and promote arousal in similar neurologic and psychiatric disorders. Here, we describe a child with severe CMS in whom zolpidem seemed to increase arousal, accelerate the resolution of mutism, and decrease emotional lability. Our report suggests that clinicians should consider using zolpidem for patients with CMS.
Charles Shyu; Kelly Burke; Mark M Souweidane; Ira J Dunkel; Stephen W Gilheeney; Timothy Gershon; Yasmin Khakoo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  33     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-23     Completed Date:  2011-04-08     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  148-9     Citation Subset:  IM    
Department of Neurology, University of Illinois at Urban-Champaign, New York, NY 10065, USA.
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MeSH Terms
Cerebellar Diseases / drug therapy,  etiology
Cerebellar Neoplasms / surgery
Child, Preschool
GABA-A Receptor Agonists / therapeutic use*
Medulloblastoma / surgery
Mutism / drug therapy*,  etiology
Neurosurgical Procedures / adverse effects*
Postoperative Complications / drug therapy*
Pyridines / therapeutic use*
Reg. No./Substance:
0/GABA-A Receptor Agonists; 0/Pyridines; 82626-48-0/zolpidem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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