Document Detail


Novel use of doxycycline in continuous-instillation negative pressure wound therapy as "wound chemotherapy".
MedLine Citation:
PMID:  20530632     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Negative-pressure wound therapy (NPWT) is frequently employed in the treatment of complex wounds. The authors present a description of real-time streaming therapy of a variety of wound chemotherapeutic agents through NPWT. Doxycycline, which acts as a competitive inhibitor of matrix metalloproteinases and tumor necrosis factor alpha and further decreases inflammation through the reduction of nitrous oxide production, may prove helpful when delivered in this manner. To the authors' knowledge, this is the first report in the literature describing this method of delivery of doxycycline.
Authors:
Christy L Scimeca; Manish Bharara; Timothy K Fisher; Nicholas Giovinco; David G Armstrong
Publication Detail:
Type:  Journal Article     Date:  2010-06-08
Journal Detail:
Title:  Foot & ankle specialist     Volume:  3     ISSN:  1938-7636     ISO Abbreviation:  Foot Ankle Spec     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101473598     Medline TA:  Foot Ankle Spec     Country:  United States    
Other Details:
Languages:  eng     Pagination:  190-3     Citation Subset:  IM    
Affiliation:
Southern Arizona Limb Salvage Alliance, Department of Surgery, University of Arizona College of Medicine, Tucson, USA.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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