| Novel use of doxycycline in continuous-instillation negative pressure wound therapy as "wound chemotherapy". | |
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MedLine Citation:
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PMID: 20530632 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Negative-pressure wound therapy (NPWT) is frequently employed in the treatment of complex wounds. The authors present a description of real-time streaming therapy of a variety of wound chemotherapeutic agents through NPWT. Doxycycline, which acts as a competitive inhibitor of matrix metalloproteinases and tumor necrosis factor alpha and further decreases inflammation through the reduction of nitrous oxide production, may prove helpful when delivered in this manner. To the authors' knowledge, this is the first report in the literature describing this method of delivery of doxycycline. |
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Authors:
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Christy L Scimeca; Manish Bharara; Timothy K Fisher; Nicholas Giovinco; David G Armstrong |
Publication Detail:
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Type: Journal Article Date: 2010-06-08 |
Journal Detail:
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Title: Foot & ankle specialist Volume: 3 ISSN: 1938-7636 ISO Abbreviation: Foot Ankle Spec Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101473598 Medline TA: Foot Ankle Spec Country: United States |
Other Details:
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Languages: eng Pagination: 190-3 Citation Subset: IM |
Affiliation:
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Southern Arizona Limb Salvage Alliance, Department of Surgery, University of Arizona College of Medicine, Tucson, USA. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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