Document Detail

Novel Upstream Approaches to Prevent Atrial Fibrillation Perpetuation.
MedLine Citation:
PMID:  25443242     Owner:  NLM     Status:  Publisher    
The mechanisms underlying atrial fibrillation (AF) in humans are poorly understood. In particular, we simply do not understand how atrial AF becomes persistent or permanent. The objective of this brief review is to address the most important factors involved in the mechanism of AF perpetuation, including structural remodeling in the form of fibrosis and electrical remodeling secondary to ion channel expression changes. In addition, I discuss the possibility that both fibrosis and electrical remodeling might be preventable when intervening pharmacologically early enough before the remodeling process reaches a point of no return.
José Jalife
Publication Detail:
Type:  REVIEW     Date:  2014-8-22
Journal Detail:
Title:  Cardiology clinics     Volume:  32     ISSN:  1558-2264     ISO Abbreviation:  Cardiol Clin     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-2     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  8300331     Medline TA:  Cardiol Clin     Country:  -    
Other Details:
Languages:  ENG     Pagination:  637-650     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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