| Novel ultrasound and DCE-MRI analyses after antiangiogenic treatment with a selective VEGF receptor inhibitor. | |
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MedLine Citation:
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PMID: 21531499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a comparison between tumor perfusion estimates acquired using contrast-enhanced MRI and motion-corrected contrast-enhanced ultrasound before and after treatment with AG-028262, a potent vascular endothelial growth factor receptor tyrosine kinase inhibitor. Antiangiogenic activity was determined by assessing weekly ultrasound and MRI images of rats with bilateral hind flank mammary adenocarcinomas before and after treatment with AG-028262. Images were acquired with a spoiled gradient, 1.5 T magnetic resonance sequence and a destruction-replenishment ultrasound protocol. For ultrasound, a time to 80% contrast replenishment was calculated for each tumor voxel; for MR imaging, a measure of local flow rate was estimated from a linear fit of minimum to maximum intensities. AG-028262 significantly decreased tumor growth and increased the time required to replenish tumor voxels with an ultrasound contrast agent from 2.66 to 4.54 s and to fill with an MR contrast agent from 29.5 to 50.8 s. Measures of flow rate derived from MRI and ultrasound demonstrated a positive linear correlation of r2 = 0.86. |
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Authors:
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Katherine D Watson; Xiaowen Hu; Chun-Yen Lai; Heather A Lindfors; Dana D Hu-Lowe; Theresa A Tuthill; David R Shalinsky; Katherine W Ferrara |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2011-04-30 |
Journal Detail:
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Title: Ultrasound in medicine & biology Volume: 37 ISSN: 1879-291X ISO Abbreviation: Ultrasound Med Biol Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-23 Completed Date: 2011-11-18 Revised Date: 2012-04-11 |
Medline Journal Info:
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Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 909-21 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Biomedical Engineering, University of California, Davis, CA 95327, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
/
complications,
diagnosis,
drug therapy Angiogenesis Inhibitors / administration & dosage* Animals Cell Line, Tumor Diffusion Magnetic Resonance Imaging / methods* Female Male Mammary Neoplasms, Experimental / complications, diagnosis*, drug therapy* Neovascularization, Pathologic / diagnosis*, drug therapy*, etiology Rats Rats, Inbred F344 Receptors, Vascular Endothelial Growth Factor / drug effects Treatment Outcome Ultrasonography / methods* |
| Grant Support | |
ID/Acronym/Agency:
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P30CA093373-06/CA/NCI NIH HHS; R01 CA103828-06A1/CA/NCI NIH HHS; R01 CA103828-09/CA/NCI NIH HHS; R01 CA112356-07/CA/NCI NIH HHS; R01 CA134659-02/CA/NCI NIH HHS; R01 CA134659-04/CA/NCI NIH HHS; R01CA103838/CA/NCI NIH HHS; R01CA134659/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors; EC 2.7.10.1/Receptors, Vascular Endothelial Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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