Document Detail

Novel therapies for the treatment of advanced prostate cancer.
MedLine Citation:
PMID:  23322116     Owner:  NLM     Status:  MEDLINE    
In recent years, great success has been achieved on many fronts in the treatment of men with metastatic castration-resistant prostate cancer (CRPC), including novel chemotherapeutics, immunotherapies, bone microenvironment-targeted agents, and hormonal therapies. Numerous agents are currently in early-phase clinical trial development for the treatment of advanced prostate cancer. These novel therapies target several areas of prostate tumor biology, including the upregulation of androgen signaling and biosynthesis, critical oncogenic intracellular pathways, epigenetic alterations, and cancer immunology. Importantly, the characterization of the prostate cancer genome offers the potential to exploit conserved genetic alterations, which may increase the efficacy of these targeted therapies. Predictive and prognostic biomarkers are urgently needed to maximize therapeutic efficacy and safety of these promising new treatments options in prostate cancer.
J M Clarke; A J Armstrong
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current treatment options in oncology     Volume:  14     ISSN:  1534-6277     ISO Abbreviation:  Curr Treat Options Oncol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-11     Completed Date:  2013-07-23     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  100900946     Medline TA:  Curr Treat Options Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-26     Citation Subset:  IM    
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MeSH Terms
Androgen Antagonists / therapeutic use*
Prostatic Neoplasms / drug therapy*,  genetics*
Signal Transduction
Steroid 17-alpha-Hydroxylase / antagonists & inhibitors*
Grant Support
Reg. No./Substance:
0/Androgen Antagonists; EC 17-alpha-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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