Document Detail

A novel technique for the semi-automated measurement of embryo volume: an intraobserver reliability study.
MedLine Citation:
PMID:  20381945     Owner:  NLM     Status:  MEDLINE    
The aim was to assess intraobserver reliability of a new semi-automated technique of embryo volumetry. Power calculations suggested 46 subjects with viable, singleton pregnancies were required for reliability analysis. Crown rump length (CRL) of each embryo was analyzed using 2-D and a 3-D dataset acquired using transvaginal ultrasound. Virtual organ computer-aided analysis (VOCAL) was used to calculate volume of gestation sac (GSV) and yolk sac (YSV) and SonoAVC (sonography-based automated volume count) was used to quantify fluid volume (FV). Embryo volume was calculated by subtracting FV and YSV from GSV. Each dataset was measured twice. Reliability was assessed using Bland-Altman plots and intraclass correlation coefficients (ICCs). Fifty-two datasets were analyzed. Median embryo volume was 1.8 cm(3) (0.1 to 8.1 cm(3)); median gestational age 7 + 4 weeks; median CRL 13 mm (2 to 29 mm). Mean difference of embryo volume measurements was 0.1cm(3) (limits of agreement [LOA] -0.3 to 0.4 cm(3)); multiples of mean (MoM) 0.38; mean difference of CRL measurements 0.3 mm (LOA -1.4 to 2.0 mm), MoM = 0.26. ICC for embryo volume was 0.999 (95%CI 0.998 to 0.999), confirming excellent intraobserver agreement. ICC for CRL was 0.996 (95%CI 0.991 to 0.998). Regression analysis showed good correlation between embryo volume and CRL (R(2) = 0.60). The new semi-automated 3-D technique provides reliable measures of embryo volume. Further work is required to assess the validity of this technique.
Shyamaly D Sur; Kannamannadiar Jayaprakasan; Nia W Jones; Jeanette Clewes; Beverley Winter; Nicola Cash; Bruce Campbell; Nicholas J Raine-Fenning
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Publication Detail:
Type:  Journal Article     Date:  2010-04-09
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  36     ISSN:  1879-291X     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-27     Completed Date:  2010-08-05     Revised Date:  2010-12-07    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  719-25     Citation Subset:  IM    
Copyright Information:
Copyright 2010 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
Nottingham University Research & Treatment Unit in Reproduction (NURTURE), Nottingham University Hospitals NHS Trust, Nottingham, UK.
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MeSH Terms
Artificial Intelligence
Embryo, Mammalian / ultrasonography*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Imaging, Three-Dimensional / methods*
Pattern Recognition, Automated / methods*
Reproducibility of Results
Sensitivity and Specificity
Ultrasonography, Prenatal / methods*
Comment In:
Ultrasound Med Biol. 2010 Dec;36(12):2144; author reply 2145   [PMID:  20870343 ]

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