Document Detail

A Novel Technique for Monitoring of Fast Variations in Brain Oxygen Tension Using an Uncoated Fluorescence Quenching Probe (Foxy AL-300).
MedLine Citation:
PMID:  21897296     Owner:  NLM     Status:  Publisher    
BACKGROUND:: A novel uncoated fluorescence quenching probe allows fast measurement of oxygen tension in vessels and tissue. The present study reports the first use of the technology for dual measurements of arterial (paO2) and brain tissue oxygen tension (ptiO2) during hypoxic challenge in a pig model. METHODS:: Eight pigs were anesthetized using fentanyl and propofol. Fluorescence quenching pO2 probes (Foxy AL-300, Ocean Optics, Dunedin, FL) were placed in the ascending aorta (Foxy-paO2) and subcortically at 14 mm in brain tissue (Foxy-ptiO2). As reference, a clark-type electrode probe (Licox-ptiO2) was placed into brain tissue close to the Foxy probe (Licox, Integra Neurosciences, Plainsboro, NJ). Measurements were taken at baseline (FiO2 1.0), during episodes of apnea, and during recovery (FiO2 1.0). Statistics: descriptive results. RESULTS:: Individual Foxy-paO2, Foxy-ptiO2, and Licox-ptiO2 courses were related to episodes of apnea. The response time of the Foxy measurements was 10 Hz. Baseline values at FiO2 1.0 were Foxy-paO2 520±120 mm Hg, Foxy-ptiO2 62±24 mm Hg, and Licox-ptiO2 55±29 mm Hg; apnea values were Foxy-paO2 64±10 mm Hg, Foxy-ptiO2 37±12 mm Hg, and Licox-ptiO2 31±16 mm Hg; recovery values at FiO2 1.0 were Foxy-paO2 478±98 mm Hg, Foxy-ptiO2 78±26 mm Hg, and Licox-ptiO2 62±32 mm Hg. CONCLUSIONS:: The present study demonstrates the feasibility of pO2 measurements in macrocirculation and cerebral microcirculation using a novel uncoated fluorescence quenching probe. The technology allows for real-time investigation of pO2 changes at a temporal resolution of 0.05 to 10 Hz.
Klaus Ulrich Klein; Stefan Boehme; Erik Kristopher Hartmann; Marc Szczyrba; Matthias David; Klaus Markstaller; Kristin Engelhard
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-5
Journal Detail:
Title:  Journal of neurosurgical anesthesiology     Volume:  -     ISSN:  1537-1921     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910749     Medline TA:  J Neurosurg Anesthesiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
*Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Medical University Vienna, Vienna, Austria †Department of Anesthesiology, Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
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