Document Detail

A novel technique for monitoring of fast variations in brain oxygen tension using an uncoated fluorescence quenching probe (Foxy AL-300).
MedLine Citation:
PMID:  21897296     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A novel uncoated fluorescence quenching probe allows fast measurement of oxygen tension in vessels and tissue. The present study reports the first use of the technology for dual measurements of arterial (paO(2)) and brain tissue oxygen tension (ptiO(2)) during hypoxic challenge in a pig model.
METHODS: Eight pigs were anesthetized using fentanyl and propofol. Fluorescence quenching pO(2) probes (Foxy AL-300, Ocean Optics, Dunedin, FL) were placed in the ascending aorta (Foxy-paO(2)) and subcortically at 14 mm in brain tissue (Foxy-ptiO(2)). As reference, a clark-type electrode probe (Licox-ptiO(2)) was placed into brain tissue close to the Foxy probe (Licox, Integra Neurosciences, Plainsboro, NJ). Measurements were taken at baseline (FiO(2) 1.0), during episodes of apnea, and during recovery (FiO(2) 1.0).
STATISTICS: descriptive results.
RESULTS: Individual Foxy-paO(2), Foxy-ptiO(2), and Licox-ptiO(2) courses were related to episodes of apnea. The response time of the Foxy measurements was 10 Hz. Baseline values at FiO(2) 1.0 were Foxy-paO(2) 520±120 mm Hg, Foxy-ptiO(2) 62±24 mm Hg, and Licox-ptiO(2) 55±29 mm Hg; apnea values were Foxy-paO(2) 64±10 mm Hg, Foxy-ptiO(2) 37±12 mm Hg, and Licox-ptiO(2) 31±16 mm Hg; recovery values at FiO(2) 1.0 were Foxy-paO(2) 478±98 mm Hg, Foxy-ptiO(2) 78±26 mm Hg, and Licox-ptiO(2) 62±32 mm Hg.
CONCLUSIONS: The present study demonstrates the feasibility of pO(2) measurements in macrocirculation and cerebral microcirculation using a novel uncoated fluorescence quenching probe. The technology allows for real-time investigation of pO(2) changes at a temporal resolution of 0.05 to 10 Hz.
Klaus Ulrich Klein; Stefan Boehme; Erik Kristopher Hartmann; Marc Szczyrba; Matthias David; Klaus Markstaller; Kristin Engelhard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurosurgical anesthesiology     Volume:  23     ISSN:  1537-1921     ISO Abbreviation:  J Neurosurg Anesthesiol     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-12     Completed Date:  2012-01-12     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8910749     Medline TA:  J Neurosurg Anesthesiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  341-6     Citation Subset:  IM    
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MeSH Terms
Anesthesia, Intravenous
Anesthetics, Intravenous
Apnea / blood,  metabolism
Blood Gas Analysis
Cerebrovascular Circulation / drug effects,  physiology
Fluorescent Dyes / diagnostic use*
Monitoring, Intraoperative / methods*
Oximetry / methods*
Oxygen / blood
Oxygen Consumption / physiology*
Reg. No./Substance:
0/Anesthetics, Intravenous; 0/Fluorescent Dyes; S88TT14065/Oxygen; UF599785JZ/Fentanyl; YI7VU623SF/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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