| A novel technique combining platelet gel, skin graft, and fibrin glue for healing recalcitrant lower extremity ulcers. | |
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MedLine Citation:
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PMID: 20187900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is no ideal procedure for the treatment of chronic skin ulcers. The use of platelet gel (PG) in this indication is raising interest. OBJECTIVE: To evaluate the safety and efficacy of a new procedure combining allogeneic single-donor PG and fibrin glue (FG) to enhance skin graft take for treating recalcitrant ulcers. MATERIALS & METHODS: Fifteen patients with 17 ulcers of various etiologies were enrolled. Skin ulcers were d?brided, and the wounds covered with moist saline dressing. Three to 14 days later, the wound bed was sprayed with PG, a thin split-thickness skin graft with multiple slits was put on the wound bed, and FG was sprayed on the skin graft. A short leg polypropylene splint was used to immobilize the skin graft. RESULTS: Most skin grafts took well. The interval between skin graft and complete wound healing ranged from 3 weeks to 2 months. No recurrence of ulcers was noted during the 3- to 18-month follow-up period. No adverse reactions were observed. CONCLUSIONS: The procedure provides advantages in skin grafting for recalcitrant ulcers because PG functions as a delivery system of powerful mitogenic and chemostatic factors and FG as a hemostatic tissue sealant that avoids the use of staples or sutures. |
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Authors:
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Tim Mo Chen; Jui-Che Tsai; Thierry Burnouf |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-19 |
Journal Detail:
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Title: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Volume: 36 ISSN: 1524-4725 ISO Abbreviation: Dermatol Surg Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-05-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504371 Medline TA: Dermatol Surg Country: United States |
Other Details:
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Languages: eng Pagination: 453-60 Citation Subset: IM |
Affiliation:
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Division of Plastic Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Chronic Disease Female Fibrin Tissue Adhesive / administration & dosage Gels Graft Survival Humans Leg Ulcer / surgery* Male Middle Aged Pilot Projects Platelet Transfusion / methods* Platelet-Rich Plasma* Prospective Studies Reconstructive Surgical Procedures / methods* Skin / surgery* Skin Transplantation / methods* Wound Healing |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Tissue Adhesive; 0/Gels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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