| A novel subcutaneous counterpulsation device: acute hemodynamic efficacy during pharmacologically induced hypertension, hypotension, and heart failure. | |
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MedLine Citation:
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PMID: 20560924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The miniaturization of mechanical assist devices and less invasive implantation techniques may lead to earlier intervention in patients with heart failure. As such, we evaluated the effectiveness of a novel, minimally invasive, implantable counterpulsation device (CPD) in augmenting cardiac function during impaired hemodynamics. We compared the efficacy of a 32-mL stroke volume CPD with a standard 40-mL intra-aortic balloon pump (IABP) over a range of clinically relevant pathophysiological conditions. Male calves were instrumented via thoracotomy, the CPD was anastomosed to the left carotid artery, and the IABP was positioned in the descending aorta. Hemodynamic conditions of hypertension, hypotension, and heart failure were pharmacologically simulated and data were recorded during CPD and IABP support (off, 1:2, 1:1 modes) for each condition. In all three pathophysiological conditions, the CPD and IABP produced similar and statistically significant (P < 0.05) increases in coronary artery blood flow normalized to the left ventricular (LV) workload. During hypotension and heart failure conditions, however, the CPD produced significantly greater reductions in LV workload and myocardial oxygen consumption as compared with the IABP. A novel 32-mL CPD connected to a peripheral artery produced equivalent or greater hemodynamic benefits than a standard 40-mL IABP during pharmacologically induced hypertension, hypotension, and heart failure conditions. |
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Authors:
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Carlo R Bartoli; Gregory C Wilson; Guruprasad A Giridharan; Mark S Slaughter; Leslie C Sherwood; Paul A Spence; Sumanth D Prabhu; Steven C Koenig |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural Date: 2010-05-31 |
Journal Detail:
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Title: Artificial organs Volume: 34 ISSN: 1525-1594 ISO Abbreviation: Artif Organs Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-11-08 Revised Date: 2011-01-31 |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
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Languages: eng Pagination: 537-45 Citation Subset: IM |
Affiliation:
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MD/PhD Program, University of Louisville School of Medicine, Louisville, KY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Counterpulsation / instrumentation* Equipment Design Heart Failure / chemically induced* Hemodynamics* Humans Hypertension / chemically induced* Hypotension / chemically induced* |
| Grant Support | |
ID/Acronym/Agency:
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1R43HL088760-01/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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Artif Organs. 2011 Jan;35(1):92-3; author reply 93-5
[PMID:
21226745
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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