Document Detail


Novel single nucleotide polymorphisms of the caprine PC1 gene and association with growth traits.
MedLine Citation:
PMID:  20607386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Proprotein convertase 1 (PC1) is an endopeptidase involved in proteolytic processing of peptide hormone precursors in granules of the regulated secretory pathway in endocrine cells. Mutations in the PC1 gene are thought to cause obesity, and multiple alternatively spliced transcript variants have been described for this gene. In this study, based on PCR-SSCP and DNA sequencing methods, polymorphisms of the PC1 gene were detected in 447 individuals from three breeds. Only the P1, P2, P3, P9, and P10 loci showed polymorphisms, and 12 SNPs in the PC1 gene were identified. Additionally, an association analysis between mutations in the 5'-UTR and four growth traits indicated that the polymorphisms were significantly associated with caprine body height (P < 0.05) and chest circumference (P < 0.01).
Authors:
Jiajie Sun; Chunlei Zhang; Xingtang Fang; Chuzhao Lei; Xianyong Lan; Hong Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-07
Journal Detail:
Title:  Biochemical genetics     Volume:  48     ISSN:  1573-4927     ISO Abbreviation:  Biochem. Genet.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-08     Completed Date:  2010-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0126611     Medline TA:  Biochem Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  779-88     Citation Subset:  IM    
Affiliation:
Institute of Cellular and Molecular Biology, Xuzhou Normal University, Jiangsu, 221116, Xuzhou, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Exons / genetics
Goats / anatomy & histology,  genetics*,  growth & development*
Introns / genetics
Polymerase Chain Reaction
Polymorphism, Single Nucleotide / genetics*
Polymorphism, Single-Stranded Conformational
Proprotein Convertase 1 / genetics*
Sequence Analysis, DNA
Chemical
Reg. No./Substance:
EC 3.4.21.93/Proprotein Convertase 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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