Document Detail


A novel preparation method for organogels: high-speed homogenization and micro-irradiation.
MedLine Citation:
PMID:  23344854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this work was to prepare organogels of Carbopol 974P NF (C974) in PEG 400 by using a novel technique, high-speed homogenization followed by microwave heating. Triclosan (TCS) was used as a model drug. C974, at concentrations ranging between 2% and 4%, was dispersed in 25 ml of PEG 400, and the dispersion was homogenised for 5 min at 24,000 rpm. The dispersion was either heated at 80°C in water bath under mechanic stirring at 200 rpm or exposed to micro-irradiation (1,200 W/1 h) for 2 min. The formulations prepared with both methods performed a well-structured gel matrix characteristic at 3% and 4% of C974 concentrations. As the concentrations of the polymer increased, the elastic properties also increased. The viscosity profiles indicated a shear-thinning system. DSC data revealed that TCS was dissolved in gel. Skin accumulation ability of TCS had been improved by these novel organogels regardless of the preparation method. TCS was still microbiologically effective after the microwave process was applied. It was determined that microwave heating is a suitable method to obtain C974 organogels. This novel production technique developed might be promising especially in industrial scale when the dramatic reduction in the preparation time and energy were considered.
Authors:
Evren Homan Gökçe; Aysu Yurdasiper; Emrah Korkmaz; Özgen Özer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-24
Journal Detail:
Title:  AAPS PharmSciTech     Volume:  14     ISSN:  1530-9932     ISO Abbreviation:  AAPS PharmSciTech     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-08-12     Revised Date:  2014-01-26    
Medline Journal Info:
Nlm Unique ID:  100960111     Medline TA:  AAPS PharmSciTech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  391-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Calorimetry, Differential Scanning
Gels*
Magnetic Resonance Spectroscopy
Organic Chemicals*
Rheology
Skin / metabolism
Chemical
Reg. No./Substance:
0/Gels; 0/Organic Chemicals
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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