| A Novel Preparation Method for Organogels: High-Speed Homogenization and Micro-irradiation. | |
| | |
MedLine Citation:
|
PMID: 23344854 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The aim of this work was to prepare organogels of Carbopol 974P NF (C974) in PEG 400 by using a novel technique, high-speed homogenization followed by microwave heating. Triclosan (TCS) was used as a model drug. C974, at concentrations ranging between 2% and 4%, was dispersed in 25 ml of PEG 400, and the dispersion was homogenised for 5 min at 24,000 rpm. The dispersion was either heated at 80°C in water bath under mechanic stirring at 200 rpm or exposed to micro-irradiation (1,200 W/1 h) for 2 min. The formulations prepared with both methods performed a well-structured gel matrix characteristic at 3% and 4% of C974 concentrations. As the concentrations of the polymer increased, the elastic properties also increased. The viscosity profiles indicated a shear-thinning system. DSC data revealed that TCS was dissolved in gel. Skin accumulation ability of TCS had been improved by these novel organogels regardless of the preparation method. TCS was still microbiologically effective after the microwave process was applied. It was determined that microwave heating is a suitable method to obtain C974 organogels. This novel production technique developed might be promising especially in industrial scale when the dramatic reduction in the preparation time and energy were considered. |
| | |
Authors:
|
Evren Homan Gökçe; Aysu Yurdasiper; Emrah Korkmaz; Ozgen Ozer |
Related Documents
:
|
17190564 - Spectra of the liquid cluster surface thermal fluctuations. 23572794 - Thermodynamic models for water sorption by garlic. 17640104 - Influence of electrophoresis waveforms in determining stochastic nanoparticle capture r... 19284624 - Particles induce apical plasma membrane enlargement in epithelial lung cell line depend... 2464894 - The mechanism accounted for the silver staining "fast techniques" development and its h... 23276424 - Modeling the transport of tio(2) nanoparticle aggregates in saturated and unsaturated g... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-24 |
Journal Detail:
|
Title: AAPS PharmSciTech Volume: - ISSN: 1530-9932 ISO Abbreviation: AAPS PharmSciTech Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100960111 Medline TA: AAPS PharmSciTech Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Faculty of Pharmacy, Department of Pharmaceutical Technology, Ege University, 35100, Bornova, Izmir, Turkey, evrenhomangokce@gmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Good Cascade Impactor Practice (GCIP) and Considerations for "In-Use" Specifications.
Next Document: Theoretical design and experimental implementation of Ag/Au electrodes for the electrochemical reduc...