Document Detail

Novel oral anticoagulants: implications in the perioperative setting.
MedLine Citation:
PMID:  20700042     Owner:  NLM     Status:  MEDLINE    
Patients undergoing surgery receive anticoagulation for perioperative thromboprophylaxis or ischemic cardiovascular disease. Because anticoagulants may also potentiate bleeding, clinicians need to understand the implications of anticoagulation in perioperative and postoperative patient management. Many newer anticoagulants that are now available or are in clinical development do not require routine coagulation monitoring, have more predictable dose responses, and have fewer interactions with other drugs and food. The most advanced oral anticoagulants in clinical development are the direct factor Xa inhibitors rivaroxaban and apixaban, and the direct thrombin inhibitor dabigatran etexilate. These agents have been evaluated in the postoperative setting in patients undergoing total hip- or knee-replacement surgery with promising results, and it remains to be seen whether these results will translate into other surgical settings. The impact of the new agents will be influenced by the balance between efficacy and safety, improved convenience, and potential cost-effectiveness benefits.
Jerrold H Levy; Nigel S Key; Marc S Azran
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anesthesiology     Volume:  113     ISSN:  1528-1175     ISO Abbreviation:  Anesthesiology     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  726-45     Citation Subset:  AIM; IM    
Department of Anesthesiology, Emory University School of Medicine and Emory Healthcare, Atlanta, Georgia 30322, USA.
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MeSH Terms
Administration, Oral
Anticoagulants / administration & dosage*
Arthroplasty, Replacement, Knee / trends
Blood Coagulation / drug effects,  physiology
Perioperative Care / methods*,  trends*
Venous Thromboembolism / etiology,  prevention & control
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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