Document Detail


A novel, minimally invasive, segmental myocardial infarction with a clear healed infarct borderzone in rabbits.
MedLine Citation:
PMID:  22447944     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ventricular arrhythmias in the setting of a healed myocardial infarction have been studied to a much lesser degree than acute and subacute infarction, due to the pericardial scarring, which results from the traditional open-chest techniques used for myocardial infarction (MI) induction. We sought to develop a segmental MI with low perioperative mortality in the rabbit that allows optimal visualization and therefore improved study of the infarction borderzone. Rabbits underwent MI using endovascular coil occlusion of the first obtuse marginal artery. Three weeks postprocedure, we evaluated our model by echocardiography and electrophysiology studies, optical mapping of isolated hearts, and histological studies. Seventeen rabbits underwent the protocol (12 MI and 5 sham) with a 92% survival to completion of the study (11 MI and 5 sham). MI rabbits demonstrated wall motion abnormalities on echocardiography while shams did not. At electrophysiological study, two MI rabbits had inducible ventricular tachycardia and one had inducible ventricular fibrillation. Isolated hearts demonstrated no pericardial scarring with a smooth, easily identifiable infarct borderzone. Optical mapping of the borderzone region showed successful mapping of peri-infarct reentry formation, with ventricular fibrillation inducible in 11 of 11 MI hearts and 1 of 5 sham hearts. We demonstrate successful high resolution mapping in the borderzone, showing delayed conduction in this region corresponding to late deflections in the QRS on ECG. We report the successful development of a minimally invasive MI via targeted coil delivery to the obtuse marginal artery with an exceptionally high rate of procedural survival and an arrhythmogenic phenotype. This model mimics human post-MI on echocardiography, gross pathology, histology, and electrophysiology.
Authors:
Ohad Ziv; Lorraine Schofield; Emily Lau; Lenny Chaves; Divyang Patel; Paul Jeng; Xuwen Peng; Bum-Rak Choi; Gideon Koren
Related Documents :
17045534 - Withdrawn: spontaneous recovery of myocardial asynergic segments following acute myocar...
25129814 - What is the value of topical cooling as an adjunct to myocardial protection?
6999564 - Insulin, prolactin, and cortisol in acute myocardial infarction.
6872374 - Hypothyroidism, raynaud's phenomenon, and acute myocardial infarction in a young woman.
9468164 - Production of nitric oxide during surgery involving cardiopulmonary bypass.
15152164 - Low-molecular-weight heparins and glycoprotein iib/iiia antagonists in acute coronary s...
Publication Detail:
Type:  Journal Article     Date:  2012-03-23
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  302     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-04     Completed Date:  2012-09-12     Revised Date:  2013-12-18    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H2321-30     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Arrhythmias, Cardiac / epidemiology,  physiopathology*
Disease Models, Animal*
Echocardiography
Electrocardiography
Electrophysiologic Techniques, Cardiac
Embolism / complications
Incidence
Male
Myocardial Infarction / etiology,  pathology*,  physiopathology*
Myocardium / pathology*
Rabbits
Grant Support
ID/Acronym/Agency:
R01 HL046005/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  THE CARDIAC RESPONSE TO DOXORUBICIN AND DEXRAZOXANE IN INTACT AND OVARIECTOMIZED YOUNG FEMALE RATS A...
Next Document:  Nitric oxide synthase, ADMA, SDMA, and nitric oxide activity in the paraventricular nucleus througho...