| A novel methodology for assessing the bounded-input bounded-output instability in QT interval dynamics: application to clinical ECG with ventricular tachycardia. | |
| | |
MedLine Citation:
|
PMID: 21984490 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The goal of this paper is to present a new methodology for assessing the bounded-input bounded-output (BIBO) stability in QT interval (QTI) dynamics from clinical ECG. The ECG recordings were collected from 15 patients who experienced ventricular tachycardia (VT). Ten-minute-long ECG recordings extracted immediately before the onset of a chosen VT, one per patient, were assembled into a VT group, while the control group comprised 10-min-long ECGs extracted 1 h before VT onset and at least 1 h after any prior arrhythmic event. Each 10-min recording was subdivided into 1-min ECG recordings (minECGs). The QTI dynamics of each minECG was defined as a function of several prior QTIs and RR intervals; the BIBO stability of this function was then assessed in the z -domain. The number of minECGs with unstable QTI dynamics (N (us)) and the frequency of premature activations (PA), f (PA) , were counted for each ECG recording and were compared between the VT and control groups. The results show that the present methodology successfully captured the instability in QTI dynamics leading to VT onset in the studied population. Significantly larger N (us) was found in the VT group compared against the control and a positive correlation between N (us) and f (PA) was identified in both groups. |
| | |
Authors:
|
Xiaozhong Chen; Natalia A Trayanova |
Publication Detail:
|
Type: Journal Article Date: 2011-10-06 |
Journal Detail:
|
Title: IEEE transactions on bio-medical engineering Volume: 59 ISSN: 1558-2531 ISO Abbreviation: IEEE Trans Biomed Eng Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-07-25 Completed Date: 2012-12-17 Revised Date: 2013-04-01 |
Medline Journal Info:
|
Nlm Unique ID: 0012737 Medline TA: IEEE Trans Biomed Eng Country: United States |
Other Details:
|
Languages: eng Pagination: 2111-7 Citation Subset: IM |
Affiliation:
|
Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA. greatfog@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Action Potentials Aged Algorithms Electrocardiography / methods* Female Humans Male Middle Aged Models, Cardiovascular Signal Processing, Computer-Assisted* Tachycardia, Ventricular / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HL082729/HL/NHLBI NIH HHS; R01 HL103428/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An Algorithm for the Estimation of the Signal-To-Noise Ratio in Surface Myoelectric Signals Generate...
Next Document: Health care financing in Asia: key issues and challenges.