| A Novel Method to Measure Serum Levels of Des-Gamma-Carboxy Prothrombin for Hepatocellular Carcinoma in Patients Taking Warfarin: a Preliminary Report. | |
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MedLine Citation:
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PMID: 22320249 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Des-gamma-carboxy prothrombin (DCP) is a useful tumor marker for hepatocellular carcinoma (HCC), but its utility was limited in patients taking vitamin K antagonists. We evaluated the newly developed method to measure serum DCP, (NX-DCP ratio) for its ability to identify DCP elevation induced by HCC in this patient subpopulation. Conventional DCP measurements and the NX-DCP ratio were compared in patients with and without HCC, all of whom were taking the vitamin K antagonist warfarin. We found no differences in conventional DCP measurements between patients with and without HCC due to warfarin administration. In contrast, the NX-DCP ratio was significantly higher in patients with HCC; the NX-DCP ratio in all patients without HCC was less than 1.50. When the cut-off was fixed at 1.50, sensitivity and specificity for HCC diagnosis were 60.0% and 100.0%, respectively, which are comparable to those of conventional DCP measurements in patients not taking warfarin. The novel NX-DCP ratio identifies patients on warfarin with elevated DCP due to HCC and is useful as a tumor marker for HCC in this patient subpopulation. © 2012 Japanese Cancer Association. |
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Authors:
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Hidenori Toyoda; Takashi Kumada; Yukio Osaki; Toshifumi Tada; Yuji Kaneoka; Atsuyuki Maeda |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-9 |
Journal Detail:
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Title: Cancer science Volume: - ISSN: 1349-7006 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101168776 Medline TA: Cancer Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Japanese Cancer Association. |
Affiliation:
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Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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