Document Detail


A Novel Method of Signal Analysis for Ablation of Wolff-Parkinson-White Syndrome.
MedLine Citation:
PMID:  21872561     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Identification of the site of a successful radiofrequency catheter ablation (RFCA) for WPW may be subjective. OBJECTIVE: To develop an automated signal analysis program to predict a successful ablation site. METHODS: Patients who underwent successful RFCA for WPW from 2008-2010 at our center were analyzed. Inclusion criteria: Age < 21yrs, loss of pre-excitation in < 5 sec, and sustained success at 3 months. Exclusion criteria: Congenital heart disease, pacing during RFCA. The standard recording system signal was filtered into low (LF 0 - ≤ 0.02 Hz) and high (HF > 0.02 - ≤ 0.45 Hz) frequencies. Software identified the beginning of the HF signal, LF and R wave peaks, LF/HF signal amplitude, and area under the HF/LF signals. Successful and unsuccessful (RF applied without AP block) signals were compared. RESULTS: 30 patients were analyzed; 16 had both successful and unsuccessful signals, 14 had a successful ablation with one RF application. Mean age was 13.7 ± 3.1 years, weight 54.9 ± 22.4 kg, and time to AP ablation 1.7 ± 1.4 sec. Significant differences were found between successful and unsuccessful signals in area under HF signal, LF amplitude, LF to R time, HF ratio, and HF area x HF ratio. A ROC of HF area x HF ratio produced an AUC of 0.89. A HF area x HF ratio of 3.1 distinguished successful from unsuccessful signals with 100% specificity and 81% sensitivity. CONCLUSIONS: Automated signal analysis retrospectively differentiated successful from unsuccessful signals in patients undergoing RFCA for WPW. This software may improve safety and efficacy of RFCA in children.
Authors:
Scott R Ceresnak; Gregory J Gates; Lynn Nappo; Hillel W Cohen; Robert H Pass
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-25
Journal Detail:
Title:  Heart rhythm : the official journal of the Heart Rhythm Society     Volume:  -     ISSN:  1556-3871     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101200317     Medline TA:  Heart Rhythm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
Assistant Professor of Pediatrics, Albert Einstein College of Medicine, Division of Pediatric Cardiology, Pediatric Arrhythmia Service, The Children's Hospital at Montefiore, 3415 Bainbridge Avenue, Rosenthal 1, Bronx, NY 10467-2490, Tel: (718) 741 - 2183, Fax: (718) 654 - 3024.
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