Document Detail


Novel mechanisms of abdominal aortic aneurysms.
MedLine Citation:
PMID:  22833280     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Abdominal aortic aneurysms (AAAs) are a common but asymptomatic disease that has high susceptibility to rupture. Current therapeutic options are limited to surgical procedures because no pharmacological approaches have been proven to decrease either expansion or rupture of human AAAs. The current dearth of effective medical treatment is attributed to insufficient understanding of the mechanisms underlying the initiation, propagation and rupture of AAAs. This review will emphasize recent advances in mechanistic studies that may provide insights into potential pharmacological treatments for this disease. While we primarily focus on recent salient findings, we also discuss mechanisms that continue to be controversial depending on models under study. Despite the progress on exploring mechanisms of experimental AAAs, ultimate validation of mechanisms will require completion of prospective double-blinded clinical trials. In addition, we advocate increased emphasis of collaborative studies using animal models and human tissues for determination of mechanisms that explore expansion and rupture of existing AAAs.
Authors:
Hong Lu; Debra L Rateri; Dennis Bruemmer; Lisa A Cassis; Alan Daugherty
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  14     ISSN:  1534-6242     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-07     Completed Date:  2013-03-29     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  402-12     Citation Subset:  IM    
Affiliation:
Saha Cardiovascular Research Center, Biomedical Biological Sciences Research Building, B243, University of Kentucky, Lexington, KY 40536-0509, USA. hong.lu@uky.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Aortic Aneurysm, Abdominal / physiopathology*,  therapy
Aortic Rupture / physiopathology*
Cytokines / metabolism
Humans
Macrophages / metabolism
Peptide Hydrolases / metabolism
Treatment Outcome
Grant Support
ID/Acronym/Agency:
HL062846/HL/NHLBI NIH HHS; HL107319/HL/NHLBI NIH HHS; HL107326/HL/NHLBI NIH HHS; HL73085/HL/NHLBI NIH HHS; HL80100/HL/NHLBI NIH HHS; P01 HL080100/HL/NHLBI NIH HHS; R01 HL062846/HL/NHLBI NIH HHS; R01 HL070239/HL/NHLBI NIH HHS; R01 HL073085/HL/NHLBI NIH HHS; R01 HL107319/HL/NHLBI NIH HHS; R01 HL107326/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; EC 3.4.-/Peptide Hydrolases
Comments/Corrections

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