| Novel MRI approaches to assess patients with multiple sclerosis. | |
| | |
MedLine Citation:
|
PMID: 20164769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE OF REVIEW: This review summarizes novel MRI approaches for the investigation of lesion burden and understanding of the pathophysiology of multiple sclerosis (MS). RECENT FINDINGS: Recent technical advances are improving our ability to detect and define the nature of focal lesions and 'diffuse' tissue damage in MS as well as the functional consequences of such structural abnormalities. New contrast agents allow to monitor the pluriformity of MS inflammation. Double inversion recovery sequences enable us to detect and monitor the evolution of MS lesions in the cortex. High and ultra-high field scanners are improving imaging of MS-related abnormalities at an unprecedented resolution. Furthermore, this new generation of scanners has the potential to ameliorate structural and functional MR studies of the disease. All of this has contributed, and is likely to continue to contribute, to the definition of the factors associated with the development of irreversible disability in MS. Finally, new analysis methods have allowed to track regional disease-related changes and are resulting in an increased correlation between MRI and clinical deficits. SUMMARY: Novel MR approaches highlighted previously unrecognized or neglected aspects of MS pathophysiology, which are likely to improve our understanding of the heterogeneous clinical manifestations of this condition. |
| | |
Authors:
|
Massimo Filippi; Maria A Rocca |
Related Documents
:
|
3614649 - Evidence for central nervous system demyelination in chronic inflammatory demyelinating... 15262739 - Corpus callosum axonal injury in multiple sclerosis measured by proton magnetic resonan... 12695199 - Three subsequent single doses of gadolinium chelate for brain mr imaging in multiple sc... 7824129 - Assessment of mri criteria for ms in japanese ms and ham/tsp. 11971079 - Mri techniques to monitor ms evolution: the present and the future. 1870499 - Low-contrast focal lesion detectability phantom for 1h mr imaging. 21701009 - Gastroenterology review and perspective: the role of cross-sectional imaging in evaluat... 11602009 - Reproducibility of interactive registration of 3d ct and mr pediatric treatment plannin... 17627149 - Ischemia of the internal capsule due to mild head injury in a child. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current opinion in neurology Volume: 23 ISSN: 1473-6551 ISO Abbreviation: Curr. Opin. Neurol. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-05 Completed Date: 2010-08-09 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9319162 Medline TA: Curr Opin Neurol Country: England |
Other Details:
|
Languages: eng Pagination: 212-7 Citation Subset: IM |
Affiliation:
|
Neuroimaging Research Unit, Division of Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan, Italy. m.filippi@hsr.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Central Nervous System
/
pathology*,
physiopathology Cerebral Cortex / pathology, physiopathology Contrast Media / diagnostic use Diagnosis, Differential Disability Evaluation Disease Progression Humans Image Processing, Computer-Assisted / methods, trends Magnetic Resonance Imaging / methods*, trends* Multiple Sclerosis / diagnosis*, physiopathology Myelin Sheath / pathology |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dopamine: what's new in migraine?
Next Document: The growing recognition of immunotherapy-responsive seizure disorders with autoantibodies to specifi...