| A Novel Intra-Oral Diabetes Screening Approach in Periodontal Patients: Results of a Pilot Study. | |
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MedLine Citation:
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PMID: 22087806 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: This pilot study examined whether a novel diabetes screening approach using gingival crevicular blood (GCB) could be used to test for hemoglobin A1c (HbA1c) during the periodontal visit. Methods: At a large periodontics clinic, finger stick blood (FSB) samples from 120 patients as well as GCB samples from those patients with adequate bleeding on probing were collected on special blood collection cards and were analyzed for HbA1c levels in a laboratory. The Pearson correlation coefficient was used to measure correlation between FSB and GCB HbA1c values for 75 paired FSB and GCB samples. A Receiver Operator Characteristic Curve (ROC) analysis was performed to determine an optimal GCB HbA1c criterion value for a positive diabetes screen. Results: For the 75 paired samples, the Pearson correlation coefficient was .842. The ROC analysis identified a criterion value of 6.3% for the GCB HbA1c test with high sensitivity (.933) and high specificity (.900) corresponding to FSB HbA1c values of 6.5% or greater (in the diabetes range). Using this GCB HbA1c criterion value for 27 additional paired samples in which there was an unidentified component observed to co-elute within the elution window of GCB HbA1c in the laboratory, there was agreement between FSB and GCB values for 24 of the pairs according to whether they were both within, or both outside of the diabetes range. Conclusions: Using a criterion value of 6.3%, GCB samples are acceptable for HbA1c testing to screen for diabetes in most persons with bleeding on probing at the GCB collection site. |
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Authors:
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Shiela M Strauss; Janet Tuthill; Geetika Singh; David Rindskopf; Jack A Maggiore; Robert Schoor; Anya Brodsky; Adi Einhorn; Amanda Hochstein; Stefanie Russell; Mary Rosedale |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-16 |
Journal Detail:
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Title: Journal of periodontology Volume: - ISSN: 1943-3670 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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College of Nursing, New York University, New York, NY. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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