Document Detail

Novel insights into human lactation as a driver of infant formula development.
MedLine Citation:
PMID:  20664213     Owner:  NLM     Status:  MEDLINE    
Progress in research on human lactation and breast milk has advanced our knowledge about the significance of breast milk for the recipient infant and the effects of various components on long-term outcomes. Recent findings have expanded our knowledge in this area. Several growth factors and cytokines are present in breast milk and their capacity to persist in the infant gut and exert their activities is likely to affect maturation of immune function, possibly affecting the development of oral tolerance. A proper balance of polyunsaturated fatty acids (n-3/n-6 ratio) may also be of significance for allergy prevention in children, emphasizing the need for the mother to achieve a balance of these fatty acids in her diet. The recent findings that specific strains of bacteria are present in breast milk and act as probiotics in the early colonization of the infant gut and that human milk oligosaccharides are specific substrates for these probiotic strains may not only affect the defense against pathogens, but also affect energy utilization and development of obesity. Previously neglected milk fat globule membranes contain several components involved in protection against infection and may be an additional arm in the multifaceted shield that breastfed infants have developed against bacterial and viral antagonists. All these findings have implications for development of improved infant formulae.
Bo Lönnerdal
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-07-21
Journal Detail:
Title:  Nestlé Nutrition workshop series. Paediatric programme     Volume:  66     ISSN:  1661-6677     ISO Abbreviation:  Nestle Nutr Workshop Ser Pediatr Program     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-28     Completed Date:  2011-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244056     Medline TA:  Nestle Nutr Workshop Ser Pediatr Program     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  19-29     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Department of Nutrition, University of California, Davis, CA, USA.
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MeSH Terms
Child Nutrition Sciences / trends*
Cytokines / administration & dosage,  analysis
Diffusion of Innovation*
Fatty Acids, Essential / administration & dosage,  analysis
Hypersensitivity / prevention & control
Infant Formula / chemistry*
Infant, Newborn
Intercellular Signaling Peptides and Proteins / administration & dosage,  analysis
Milk, Human / chemistry*,  microbiology
Nutritional Requirements
Probiotics / administration & dosage
Reg. No./Substance:
0/Cytokines; 0/Fatty Acids, Essential; 0/Intercellular Signaling Peptides and Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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