| A Novel Immune Evasion Mechanism of LMP-1, an EBV-Primary Oncogene, in Nasopharyngeal Carcinoma. | |
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MedLine Citation:
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PMID: 21865718 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Nasopharyngeal carcinoma is an Epstein-Barr virus (EBV)-associated tumor. Viruses that are associated with malignant transformation have evolved unique mechanisms to interfere with this interaction to evade antiviral T cell responses. EBV exploits many immune evasive strategies to successfully establish a latent infection in B cells. CD8+ T cell responses to LMP-1 are generally very low and rarely detected in healthy virus carriers. Activation of the NF-kB pathway by EBV-LMP-1 leads to an upregulation of the MHC class I antigen-processing pathway. Paradoxically, LMP-1itself induces a subdominant CD8+ T cell response and appears to have evolved to avoid immune recognition. An expression of LMP-1 in human cells enhanced the trans-presentation of CD8+ T cell epitopes; however, cis-presentation of LMP-1-derived epitopes was severely impaired. Deletion of the first transmembrane domain of LMP-1, which prevented self-aggregation, significantly enhanced the cis-presentation of T cell epitopes from this protein, whereas it lost its ability to upregulate trans-presentation. These results delineate a novel mechanism of immune evasion, which renders a virally encoded oncogene inaccessible to the conventional MHC class I pathway limiting its cis-presentation. |
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Authors:
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Tomokazu Yoshizaki |
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Publication Detail:
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Type: Journal Article Date: 2011-08-18 |
Journal Detail:
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Title: Advances in oto-rhino-laryngology Volume: 72 ISSN: 1662-2847 ISO Abbreviation: Adv. Otorhinolaryngol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-08-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242534 Medline TA: Adv Otorhinolaryngol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 157-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Division of Otolaryngology, Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Takaramachi, Kanazawa, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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