Document Detail


A Novel Immune Evasion Mechanism of LMP-1, an EBV-Primary Oncogene, in Nasopharyngeal Carcinoma.
MedLine Citation:
PMID:  21865718     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Nasopharyngeal carcinoma is an Epstein-Barr virus (EBV)-associated tumor. Viruses that are associated with malignant transformation have evolved unique mechanisms to interfere with this interaction to evade antiviral T cell responses. EBV exploits many immune evasive strategies to successfully establish a latent infection in B cells. CD8+ T cell responses to LMP-1 are generally very low and rarely detected in healthy virus carriers. Activation of the NF-kB pathway by EBV-LMP-1 leads to an upregulation of the MHC class I antigen-processing pathway. Paradoxically, LMP-1itself induces a subdominant CD8+ T cell response and appears to have evolved to avoid immune recognition. An expression of LMP-1 in human cells enhanced the trans-presentation of CD8+ T cell epitopes; however, cis-presentation of LMP-1-derived epitopes was severely impaired. Deletion of the first transmembrane domain of LMP-1, which prevented self-aggregation, significantly enhanced the cis-presentation of T cell epitopes from this protein, whereas it lost its ability to upregulate trans-presentation. These results delineate a novel mechanism of immune evasion, which renders a virally encoded oncogene inaccessible to the conventional MHC class I pathway limiting its cis-presentation.
Authors:
Tomokazu Yoshizaki
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Publication Detail:
Type:  Journal Article     Date:  2011-08-18
Journal Detail:
Title:  Advances in oto-rhino-laryngology     Volume:  72     ISSN:  1662-2847     ISO Abbreviation:  Adv. Otorhinolaryngol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-08-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242534     Medline TA:  Adv Otorhinolaryngol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  157-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Division of Otolaryngology, Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Takaramachi, Kanazawa, Japan.
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