| Novel Hormonal Delivery Method Using the Ink-Jet Technology: Application to Pulmonary Insulin Therapies. | |
| | |
MedLine Citation:
|
PMID: 21406017 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Abstract Background: A device developed based on ink-jet printer technology can precisely control the size and volume of droplets ejected. Here, we evaluated the application of this technology to the pulmonary administration of insulin mist as a therapeutic measure for diabetes. Methods: Insulin ejected from the ink-jet device was initially characterized by high-performance liquid chromatography (HPLC) and mass spectrometry. Its effects on d-glucose uptake rate by L6 cells were then investigated. Next, different insulin solutions (with or without additives or ink-jet processing) were subcutaneously administered, and their pharmacodynamic features were evaluated. Finally, decreases in plasma glucose level in rats were examined after ventilator-assisted pulmonary administration of insulin mist. Results: Neither the HPLC nor the mass spectrometry profile of insulin was altered by the ink-jet process. The d-glucose uptake rate by L6 cells that received the recovered aerosolized insulin solution was similar to that of cells treated with control insulin, at 107%. Neither the addition of additives nor the ink-jet process used for insulin aerosolization impaired the plasma glucose-lowering action of subcutaneously injected insulin. Similarly, the efficacy of pulmonary insulin administration was not affected by the additives or the ink-jet process. Plasma glucose levels showed a trend towards decreasing after ventilator-assisted pulmonary administration of insulin mist. Plasma insulin level increased 30 min after the inhalation. Conclusions: The ink-jet process did not affect the quality or biological activity of insulin, suggesting the potential use of the ink-jet device for insulin inhalation therapy for diabetes. |
| | |
Authors:
|
Masami Nemoto; Yoshito Hiki; Kousuke Shimada; Nozomu Nakai; Kei Fujimoto; Sachiko Inoue; Naoko Sakurada; Hideki Kaneko; Masaru Sugita; Masataka Okabe; Takashi Sasaki |
Related Documents
:
|
12560157 - Effect of combination therapy with dipyridamole and quinapril in diabetic nephropathy. 17314207 - Fasting insulin modifies the relation between age and renal function. 3093617 - Urinary excretion and renal production of prostaglandins e2, f2 alpha, and thromboxane ... 6241267 - Inhibition of glucose reabsorption induced by 6-aminonicotinamide in the rat kidney. 15087587 - Immunodip: an improved screening method for microalbuminuria. 1364977 - Vitamin e and a and periodontium in pregnant diabetics. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-15 |
Journal Detail:
|
Title: Diabetes technology & therapeutics Volume: - ISSN: 1557-8593 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100889084 Medline TA: Diabetes Technol Ther Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1 Department of General Internal Medicine, Jikei University School of Medicine , Aoto Hospital, Tokyo, Japan . |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Chinese Diabetes Risk Score for Screening of Undiagnosed Diabetes and Abnormal Glucose Tolerance.
Next Document: Qualitative Evaluation of a Mobile Phone and Web-Based Collaborative Care Intervention for Patients ...