| Novel Hexahydropyridoindole Derivative as Prospective Agent Against Oxidative Damage in Pancreatic βCells. | |
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MedLine Citation:
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PMID: 22313311 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The potential protective effect of (±)-8-methoxy-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid ethyl ester (II) was assessed against hydrogen peroxide (H2O2)-cytotoxicity in rat pancreatic INS-1E β cells and compared with the effect of the related pyridoindole, stobadine (I), a promising indole-type reference antioxidant. Only pre-treatment with the compound (II) led to a significant preservation of the metabolic and secretory functions of the cells exposed to H2O2. The caspase-9 and -3 activities, as well as the early apoptotic changes of plasma membrane, were suppressed in the cells pre-incubated with both of compounds tested. However, only pyridoindole (II) inhibited profoundly the time-delayed apoptotic changes, These results suggest that pyridoindole (II) characterized by enhanced intrinsic antioxidant efficiency, may protect ?? cells against cytotoxic effects of H2O2, involved in the development of both type 1 and type 2 diabetes. |
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Authors:
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Lucia Rackova; Ahmet Cumaoglu; E Umit Bagrιacιk; Milan Stefek; Pierre Maechler; Cimen Karasu |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Medicinal chemistry (Shariqah (United Arab Emirates)) Volume: 7 ISSN: 1875-6638 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2012-2-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101240303 Medline TA: Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: 711-717 Citation Subset: - |
Affiliation:
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Department of Medical Pharmacology, Faculty of Medicine, Gazi University, Ankara, Turkey. cimenkrs@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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