| Novel HPV-6 variants of human papillomavirus causing recurrent respiratory papillomatosis in southern Africa. | |
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MedLine Citation:
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PMID: 21875449 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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SUMMARYThere is currently no information regarding the genetic diversity of HPV-6 variants circulating in South Africa. The aim of this study was to determine the HPV-6 variants affecting patients with recurrent respiratory papillomatosis, to determine whether mutations correlate with disease severity and identify molecular determinants of virulence with prognostic relevance. HPV-6 variants were identified based on genome changes within the 712-991 bp region encompassing the non-coding region (URR) of the genome, with variations in length resulting from insertions and duplications, and the 453-bp gene encoding the E6 protein. Based on manual comparison of sequence data from the URR, the isolates were identified as HPV-6a and HPV-6vc variants. Three novel HPV-6 variants were identified: one based on a mutation in the E6 region; two based on changes in the URR including a unique substitution detected in three isolates and an insertion and 170-bp duplication in the URR genome in one patient, who had clinical features of severe disease. |
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Authors:
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C E Combrinck; R Y Seedat; C Randall; Y Roodt; F J Burt |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-30 |
Journal Detail:
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Title: Epidemiology and infection Volume: - ISSN: 1469-4409 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703737 Medline TA: Epidemiol Infect Country: - |
Other Details:
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Languages: ENG Pagination: 1-7 Citation Subset: - |
Affiliation:
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Department of Medical Microbiology and Virology, Faculty of Health Science, University of the Free State, Bloemfontein, South Africa. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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